Transmembrane Receptors
7-Transmembrane receptors (7-TM receptors), also known as G-protein-coupled receptors, are the largest family of cell surface receptors in the human genome and are integral membrane proteins containing seven membrane-spanning helices. 7-TMs are coupled to intracellular heterotrimeric G proteins, and on ligand binding undergo a conformational change which is transmitted to the G protein.
7-TM receptors are activated by a wide variety of ligands such as nucleotides, peptides, amines, Ca2+ and photons, and are classed into 6 groups – Class A, rhodopsin-like, Class B, the secretin receptor family, Class C, metabotropic glutamate receptors, Class D, fungal mating pheromone receptors, Class E, cyclic AMP receptors and Class F, the frizzled/smoothened receptors.
Mutations in GPCR can cause acquired and inherited diseases such as retinitis pigmentosa, hypo- and hyperthyroidism, nephrogenic diabetes insipidus, fertility disorders, and cancer but due to their large number, widespread distribution and important roles in cell physiology and biochemistry, 7-TM’s have an important role in human medicine and are the target of around half of all modern medicinal drugs.
Showing 65–80 of 150 results
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BNP-32, porcineSPKTMRDSGCFGRRLDRIGSLSGLGCNVLRRY-acid
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Bombesin
[Pyr]-QRLGNQWAVGHLM-amide
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Calcitonin, RatCGNLSTCMLGTYTQDLNKFHTFPQTSIGVGAP-amide
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Calcitonin, SalmonCSNLSTCVLGKLSQELHKLQTYPRTNTGSGTP-amide, Disulfide bridge: Cys1-Cys7
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CCK octapeptide Cholecystokinin (26-33)
DYMGWMDF-amide
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CRF human, rat
SEEPPISLDLTFHLLREVLEMARAEQLAQQAHSNRKLMEII-amide
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Cyclo(-RGDyK)
Cyclo(-RGDyK)
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Cyclo(RGDfC)
Cyclo(RGDfC) where f is D-phenylalanine
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Cyclo(RGDfK)
Cyclo(RGDfK) where f is D-Phenylalanine
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Exendin 3 (9-39) amide
DLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-amide
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Exendin 4 (4–39)
GTFTSDLSKQMEEEAVRLFIE-W-LKNGGPSSGAPPPS-amide
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Exendin-4 [Lys(AF647)]
HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-[K(AF647 DBCO)]-amide
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FREG peptide
DPHIKLQLQAE-acid
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Fz7-21Ac-LPSDDLEFWCHVMY-amide
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Galanin (1-13)
G-W-TLNSAGYLLGP-amide
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Galanin (1-15) Porcine, Rat
GWTLNSAGYLLGPHA -amide
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