Cyclo(-RGDyK) is a potent and selective inhibitor of the αvβ3 integrin receptor.
Catalogue number crb1001169 Molecular Weight 619.3 Sequence (one letter code)
Sequence (three letter code)
Purity >95% Storage -20°C References
Dai et al (2000) An improved synthesis of a selective αvβ3-integrin antagonist cyclo(-RGDfK-). Tetrahedron Letters 41 (33) 6295
Manufactured in: United Kingdom
The cyclic pentapeptide cyclo(-Arg-Gly-Asp-d-Phe-Lys-) is a highly potent and selective inhibitor for the αvβ3 integrin receptor. A related compound, cyclo(-Arg-Gly-Asp-d-Phe-Val), is a promising anti-cancer drug candidate; it inhibits angiogenesis and induces apoptosis in vascular cells.
Cyclic RGD-containing peptides are selective antagonists of integrins, proteins that play important roles in cell-cell and cell-matrix interactions. In a suitably labelled form, these peptides may serve as useful tools for diagnostic imaging and peptide targeted therapy of some types of cancer.