Transmembrane Receptors
7-Transmembrane receptors (7-TM receptors), also known as G-protein-coupled receptors, are the largest family of cell surface receptors in the human genome and are integral membrane proteins containing seven membrane-spanning helices. 7-TMs are coupled to intracellular heterotrimeric G proteins, and on ligand binding undergo a conformational change which is transmitted to the G protein.
7-TM receptors are activated by a wide variety of ligands such as nucleotides, peptides, amines, Ca2+ and photons, and are classed into 6 groups – Class A, rhodopsin-like, Class B, the secretin receptor family, Class C, metabotropic glutamate receptors, Class D, fungal mating pheromone receptors, Class E, cyclic AMP receptors and Class F, the frizzled/smoothened receptors.
Mutations in GPCR can cause acquired and inherited diseases such as retinitis pigmentosa, hypo- and hyperthyroidism, nephrogenic diabetes insipidus, fertility disorders, and cancer but due to their large number, widespread distribution and important roles in cell physiology and biochemistry, 7-TM’s have an important role in human medicine and are the target of around half of all modern medicinal drugs.
Showing 17–32 of 150 results
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α-CGRP (mouse, rat)
SCNTATCVTHRLAGLLSRSGGVVKDNFVPTNVGSEAF-amide
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2-Furoyl-LIGRL-amide(2-Furoyl)-LIGRL-amide
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5-FAM-Fz7-21
[5-FAM]-LPSDDLEFWCHVMY-amide
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Acetyl-TGF-beta 2-LAPβ (259– 269)Acetyl-YTSGDQKTIKS-amide
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ACTH (1-10) HumanSYSMEHFRWG-acid
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ACTH (1-17) HumanSYSMEHFRWGKPVGKKR-acid
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ACTH (1-24) -[5-FAM]SYSMEHFRWGKPVGKKRRPVKVYP-[5-FAM]
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ACTH (1-24) Human
SYSMEHFRWGKPVGKKRRPVKVYP-acid
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ACTH (1-39) HumanSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEF-acid
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ACTH (11-24)KPVGKKRRPVKVYP-amide
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ACTH (18-39) HumanRPVKVYPNGAEDESAEAFPLEF-acid
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ACTH (7-38) HumanFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLE-acid
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ACTH (7-39) CysFR-W-GKPVGKKRRPVKVYPNGAEDESAEAFPLEFC-amide
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ACTH (7-39) humanFR-W-GKPVGKKRRPVKVYPNGAEDESAEAFPLEF-acid
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AF12198Ac-FEWTPGWYQJYALPL-amide
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Alexamorelin
Ala-His-[D-2-methyl-Trp]-Ala-Trp-[D-Phe]-Lys-amide
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