Galanin (1-15) Porcine, Rat

GWTLNSAGYLLGPHA -amide

  • Description

  • Application Data

Description

An N-terminal fragment of galanin (1-15); galanin is a widely distributed neuropeptide with a wide variety of roles including weight management and mental health.

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Application Data

Catalogue number crb1000400
Molecular Weight 1554.8
Sequence (one letter code)

GWTLNSAGYLLGPHA -amide

Sequence (three letter code)

H-Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-His-Ala-NH2

Purity >95%
cas 112747-70-3
References

Narváez et al., (2000). The galanin receptor antagonist M40 blocks the central cardiovascular actions of the galanin N-terminal fragment (1-15). Eur J Pharmacol., 399(2): 197. PMID: 10884520.

Ruczynsk et al., (2002). Effects of porcine galanin, galanin (1–15) NH2 and its new analogues on glucose-induced insulin secretion. Pol J Pharmacol, 54(2): 133.

 

Manufactured in: United Kingdom
Data Sheet Material Safety Data Sheet (MSDS)

Galanin is a widely distributed neuropeptide in the central nervous system (CNS), peripheral regions and endocrine system. Galanin interacts with 3 receptor subtypes, GalR1-3 G protein-coupled receptors inserted into the plasma membrane. Galanin has a role in energy homeostasis. Central injections of galanin to the amygdala led to food intake in rats. Galanin also acts in the CNS to inhibit neurotransmitter release, such as acetylcholine. Galanin has been implicated in numerous neurological conditions, including Alzheimer’s disease, depression, and epilepsy. A better understanding of the galinergic signalling pathways may uncover a source for therapeutics for conditions such as epilepsy.

Unlike human galanin, full-length porcine galanin contains only 29 amino acids and is C-terminally amidated. The first 15 residues are still highly conserved.  The best-recognized effect of galanin on the endocrine pancreas is the inhibition of insulin secretion in vitro and in vivo on multiple model systems, including rats, dogs, and mice. However, the same effect cannot be achieved at the same concentrations in human models with infusions of porcine galanin. Structural activity and point mutation studies show that the N-terminal (1-15) fragment is vital for the interaction/activation of the GAL receptor and the inhibition of insulin secretion.

Galanin (1-15) Porcine, Rat

Cat No.Pack SizePriceQty.
0.5mg£85.00
1mg£110.00
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