With over 35 years experience, Cambridge Research Biochemicals is a leading independent producer of custom-made peptide and antibody tools, supplying researchers in the pharmaceutical, life science and academic sectors worldwide. The primary applications of its products are as custom-made, laboratory scale reagents for proof of principle studies within early phase drug discovery and to support biomarker programmes in clinical studies. The company produces all ﬂavours of peptides from simple to modiﬁed, stable and radio-labelled to dye labelled from milligrams to gram-scale to the highest levels of purity. CRB has an enviable track record for generating target specific antibodies with modifications and labelling.
“In many different model organisms and cell types we had observed a circadian rhythm in the oxidation state of the highly conserved 2-cys peroxiredoxin family of anti-oxidants. As we investigated the underlying mechanism however, we found that we were hindered by variations in the specificity of commercially available antisera against this oxidative protein modification.
CRB generated a highly specific affinity-purified polyclonal, additionally depleted for activity against unmodified peroxiredoxin.
This tool allowed us to further validate our original findings and obviated any need to take batch variation into account, thereby increasing experimental reproducibility. CRB’s service was efficient and professional, and very much tailored towards our particular needs. I do not hesitate to recommend them to colleagues.”
Read the full testimonial and story in our Case Study.