Technical information for peptide and antibody products


CRB routinely uses the radioisotopes Tritium and Carbon-14 for the labelling of peptides, whereas Iodine-125 is used for labelling of proteins and antibodies via iodination of tyrosine residues. Tritium and Carbon-14 allow for labelling at high specific activities without compromising the biological activity of the peptide.

Radioisotopes for radiolabelling of Peptides and Proteins
Tritium Carbon-14 Iodine-125
Common specific activity range 10-100Ci/matom 50-100mCi/matom 2170Ci/matom
Half life 12.3 years 5730 years 60 days
Residues frequently labelled Proline, leucine, tyrosine, phenylalanine, alanine Glycine, N-acetyl Tyrosine
Energy of ß-particle max 18.6keV
mean 5.7keV
max 156keV
mean 49keV
electron capture