Cambridge Research Biochemicals (CRB) has recently acquired the rights to a novel and patentable method, SELPEPCON™ for parallel assembly of a large number of peptide-therapeutic cargo combinations.
CRB is now offering custom–made libraries of peptide-cargo conjugates to help accelerate the delivery and development of new therapeutics.
Cargo Types. The technology is available immediately for Peptide Nucleic Acids (PNA), peptide cargoes and peptide conjugates of a Phosphorodiamidate Morpholino Oligonucleotide (PMO) cargo.
Antisense PNA or PMO, as with other oligonucleotide types, are poor in cell uptake. A researcher may wish to search a CPP library for a suitable cell delivery peptide attachment for a particular cell type under study. Further, many peptide inhibitors of cellular process are poor at entering cells and a CPP may help to enhance cellular activity. Customers may wish to begin or refine a drug discovery process for an antisense oligonucleotide or peptide inhibitor lead.
A library of cell-penetrating peptide (CPP)-cargo conjugates for rapid identification of optimal carriers is now available:
Cambridge Research Biochemicals (CRB) has collaborated with UK expert, Dr John Howl (Pantechnia, University of Wolverhampton) to design and supply a kit of cell penetrating peptides suitable for different cargo molecules.
CRB also offers a cell penetrating peptide design service and conjugation to clients’ cargoes.