Exendin 3 (9-39) amide
DLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-amide

Description
Application Data

Description: Truncated exendin-3 is a potent and selective glucagon-like peptide-1 receptor (GLP-1R) antagonist. This is a 30-peptide sequence from the N terminal region.

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Application Data

Catalogue number	crb1000986
Molecular Weight	3367.7
Sequence (one letter code)	DLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-amide
Sequence (three letter code)	H-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2
Purity	>95%
cas	133514-43-9
Storage	-20°C
References	Gasbjerg et al., (2021). Exendin (9‐39) NH2: Recommendations for clinical use based on a systematic literature review. Diabetes Obes Metab, 23(11): 2419. doi: 10.1111/dom.14507. Gault et al., (2003). Effects of the novel (Pro3) GIP antagonist and exendin (9–39) amide on GIP-and GLP-1-induced cyclic AMP generation, insulin secretion and postprandial insulin release in obese diabetic (ob/ob) mice: evidence that GIP is the major physiological incretin. Diabetologia, 46(2): 222. doi: 10.1007/s00125-002-1028-x.
Manufactured in:	United Kingdom

Data Sheet Material Safety Data Sheet (MSDS)

Originally identified in Heloderma horridum horridum (Mexican beaded lizard), exendin-3 shares homology with vasoactive intestinal peptide (VIP), secretin, helospectin I and II and helodermin. Exendin-3 increases cellular cAMP levels and amylase release from pig pancreatic cells.

Truncated exendin-3 is a potent and selective GLP-1 receptor antagonist. It inhibits cAMP production and insulin release induced by GLP-1, exendin-3, and exendin-4. It also blocks the inhibitory effect of GLP-1 on food intake in rats. Exendin 3 (9-39) amide is being considered for clinical use in obese patients. This is based on the extensive and consistent data demonstrating its effectiveness as a tool to improve fasting and postprandial levels of glucose and glucagon.

Exendin 3 (9-39) amide

Cat No.	Pack Size	Price	Qty.
crb1000986h	0.5mg	£95.00	Exendin 3 (9-39) amide 0.5mg quantity — OR —
crb1000986j	1mg	£130.00	Exendin 3 (9-39) amide 1mg quantity — OR —

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Exendin 3 (9-39) amide
DLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-amide

Description

Application Data

Description

Application Data

Exendin 3 (9-39) amide

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