Exendin 3 (9-39) amide
DLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-amide
Description
Application Data
Description
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Truncated exendin-3 is a potent and selective glucagon-like peptide-1 receptor (GLP-1R) antagonist. This a 30 peptide sequence from the N terminal region.
Application Data
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Data Sheet Material Safety Data Sheet (MSDS)Catalogue number crb1000986 Molecular Weight 3367.7 Sequence (one letter code) DLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-amide
Sequence (three letter code) H-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2
Purity >95% cas 133514-43-9 Storage -20°C References Raufman et al., (1991). Exendin-3, a novel peptide from the Heloderma horridum venom, interacts with vasoactive intestinal peptide receptors and a newly described receptor on dispersed acini from guinea pig pancreas. J.Biol.Chem., 266: 2897 PMID: 1704369.
Thorens et al., (1993). Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor. Diabetes, 42: 1678. PMID: 8405712.
Manufactured in: United Kingdom Originally identified in Heloderma horridum horridum (Mexican beaded lizard), exendin-3 shares homology with vasoactive intestinal peptide (VIP), secretin, helospectin I and II and helodermin. Exendin-3 stimulates the increases in cellular cAMP levels and amylase release from pig pancreatic cells.
Truncated exendin-3 is a potent and selective GLP-1 receptor antagonist. It inhibits cAMP production and insulin release induced by GLP-1, exendin-3, and exendin-4. It also blocks the inhibitory effect of GLP-1 on food intake in rats.