Transmembrane Receptors
7-Transmembrane receptors (7-TM receptors), also known as G-protein-coupled receptors, are the largest family of cell surface receptors in the human genome and are integral membrane proteins containing seven membrane-spanning helices. 7-TMs are coupled to intracellular heterotrimeric G proteins, and on ligand binding undergo a conformational change which is transmitted to the G protein.
7-TM receptors are activated by a wide variety of ligands such as nucleotides, peptides, amines, Ca2+ and photons, and are classed into 6 groups – Class A, rhodopsin-like, Class B, the secretin receptor family, Class C, metabotropic glutamate receptors, Class D, fungal mating pheromone receptors, Class E, cyclic AMP receptors and Class F, the frizzled/smoothened receptors.
Mutations in GPCR can cause acquired and inherited diseases such as retinitis pigmentosa, hypo- and hyperthyroidism, nephrogenic diabetes insipidus, fertility disorders, and cancer but due to their large number, widespread distribution and important roles in cell physiology and biochemistry, 7-TM’s have an important role in human medicine and are the target of around half of all modern medicinal drugs.
Showing 81–96 of 150 results
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Galanin (1-17) PorcineG-W-TLNSAGYLLGPHAID-amide
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Galanin (13-20) Mouse
PHAIDNHR-amide
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Galanin (2-12) acid
WTLNSAGYLLG-acid
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Galanin (2-13)
WTLNSAGYLLGP-amide
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Galanin (2-13)-Biotin
WTLNSAGYLLGP-[Biotin]
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Galanin (2-30) acid
WTLNSAGYLLGPHAVGNHRSFSDKNGLTS-acid
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Galanin (3-13)
TLNSAGYLLGP-amide
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Galanin (3-13)-Biotin
TLNSAGYLLGP-[Biotin]
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Galanin Human
GWTLNSAGYLLGPHAVGNHRSFSDKNGLTS-acid
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Galanin Mouse, Rat
GWTLNSAGYLLGPHAIDNHRSFSDKHGLT-amide
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Galantide
GWTLNSAGYLLGPQQFFGLM-amide
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Gastrin Releasing Peptide, human
VPLPAGGGTVLTKMYPRGNHWAVGHLM-amide
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Ghrelin Human
GSS(n-octanoyl)FLSPEHQRVQQRKESKKPPAKLQPR-acid
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Ghrelin Rat, Mouse
GSS(n-octanoyl)FLSPEHQKAQQRKESKKPPAKLQPR-acid
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GIP (1-42)-[C] human
YAEGTFISDYSIAMDKIHQQDFVNWLLAQKGKKNDWKHNITQ-[C]-amide
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GIP (Pro 3)
YAPGTFISDYSIAMDKIHQQDFVNWLLAQKGKKNDWKHNITQ-amide
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