Ghrelin Rat, Mouse GSS(n-octanoyl)FLSPEHQKAQQRKESKKPPAKLQPR-acid
Rat/mouse peptide hormone modified at position 3 by a fatty acid. Ghrelin is involved in appetite stimulation and growth hormone release.
Catalogue number crb1000253 Molecular Weight 3314.8 Sequence (one letter code) GSS(n-octanoyl)FLSPEHQKAQQRKESKKPPAKLQPR-acid Sequence (three letter code) H-Gly-Ser-Ser(2-octanoyl)-Phe-Leu-Ser-Pro-Glu-His-Gln-Lys-Ala-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg-OH Molecular Weight 3314.8 Purity >95% References
Colldén et al (2017) Therapeutic Potential of Targeting the Ghrelin Pathway. Int. J. Mol. Sci. 18(4) 798 PMID: 28398233
Edwards and Abizaid, A (2017) Clarifying the Ghrelin System’s Ability to Regulate Feeding Behaviours Despite Enigmatic Spatial Separation of the GHSR and Its Endogenous Ligand. Int. J. Mol. Sci. 18(4) 859 PMID: 28422060
Pereira et al (2017) The Impact of Ghrelin in Metabolic Diseases: An Immune Perspective. J. Diabetes Res. 1 PMID: 29082258
Ghrelin is a peptide hormone mainly produced in the stomach. Ghrelin is involved in several physiological processes, including: feeding and lipid accumulation; stress response; anxiety; cardiac performance; immunity and inflammation; taste sensation; reward-seeking behaviour; regulation of glucose metabolism and thermogenesis; memory; motivation and learning.
Ghrelin exerts its actions by binding the growth hormone secretagogue receptor (GHSR) which is found largely in the hypothalamic and mesolimbic brain regions as well as in peripheral organs (adipose tissue, adrenals, stomach).
Ghrelin is produced by the cleavage of the precursor peptide preproghrelin. The attachment of a fatty acid to its serine 3 residue produces a form capable of activating GHSR.
Gherlin is considered a valuable target for the treatment of conditions such as anorexia, cachexia, sarcopenia, cardiopathy, neurodegenerative disorders, renal and pulmonary disease, gastrointestinal disorders, inflammatory disorders and metabolic syndrome.