Ghrelin Rat, Mouse

GSS(n-octanoyl)FLSPEHQKAQQRKESKKPPAKLQPR-acid

  • Description

  • Application Data

Description

Ghrelin Rat/mouse orexigenic peptide hormone is modified at position 3 by a fatty acid. Ghrelin is involved in appetite stimulation and growth hormone release.

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Application Data

Catalogue number crb1000253
Molecular Weight 3314.8
Sequence (one letter code)

GSS(n-octanoyl)FLSPEHQKAQQRKESKKPPAKLQPR-acid

Sequence (three letter code)

H-Gly-Ser-Ser(2-octanoyl)-Phe-Leu-Ser-Pro-Glu-His-Gln-Lys-Ala-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg-OH

Purity >95%
cas 258338-12-4
References

Colldén et al (2017) Therapeutic Potential of Targeting the Ghrelin Pathway. Int. J. Mol. Sci. 18(4) 798 PMID: 28398233

Edwards and Abizaid, A (2017) Clarifying the Ghrelin System’s Ability to Regulate Feeding Behaviours Despite Enigmatic Spatial Separation of the GHSR and Its Endogenous Ligand. Int. J. Mol. Sci. 18(4) 859 PMID: 28422060

Pereira et al (2017) The Impact of Ghrelin in Metabolic Diseases: An Immune Perspective. J. Diabetes Res. 1 PMID: 29082258

Manufactured in: United Kingdom
Data Sheet Material Safety Data Sheet (MSDS)

Ghrelin is involved in several physiological processes, including feeding and lipid accumulation, stress response; anxiety; cardiac performance; immunity and inflammation, taste sensation, reward-seeking behaviour, regulation of glucose metabolism and thermogenesis, memory, motivation and learning.

Ghrelin is a peptide hormone that typically has a serine at the third residue and relies on modification with a fatty acid to give ghrelin its functional activity. In its modified form, ghrelin is an endogenous ligand for the pituitary gland’s growth hormone receptor (GHS-R) and stimulates growth hormone release. Rat/mouse ghrelin differs from the human form at positions 11 and 12 (RV) in rats to (KA) in humans.

Ghrelin acts on the hypothalamic arcuate nucleus as an orexigenic agent to stimulate appetite. Ghrelin is produced in the stomach as a precursor peptide preproghrelin, cleaved to ghrelin. Ghrelin circulates in the blood and can cross the blood-brain barrier. Levels of ghrelin respond to fasting conditions and allow signals about the energy status to be transmitted from the peripheral organs to the central nervous system to maintain energy homeostasis.

Ghrelin is a valuable target for treating conditions such as anorexia, cachexia, sarcopenia, cardiopathy, neurodegenerative disorders, renal and pulmonary disease, gastrointestinal disorders, inflammatory disorders and metabolic syndrome.

Ghrelin Rat, Mouse

Cat No.Pack SizePriceQty.
1mg£220.00
0.5mg£170.00
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