Galanin Mouse, Rat

GWTLNSAGYLLGPHAIDNHRSFSDKHGLT-amide

  • Description

  • Application Data

Description

Galanin Mouse, Rat is a non-selective galanin receptor agonist for GalR1-3 leading to growth hormone release and appetite increase.

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Application Data

Catalogue number crb1000482
Molecular Weight 3162.6
Sequence (one letter code)

GWTLNSAGYLLGPHAIDNHRSFSDKHGLT-amide

Sequence (three letter code)

H-Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-His-Ala-Ile-Asp-Asn-His-Arg-Ser-Phe-Ser-Asp-Lys-His-Gly-Leu-Thr-NH2

Purity >95%
cas 114547-31-8
References

Mazarati (2004). Galanin and galanin receptors in epilepsy. Neuropeptides, 38(6): 331. doi: 10.1016/j.npep.2004.07.006.

Robinson et al., (2006). Galanin/GALP receptors and CNS homeostatic processes. CNS Neurol Disord Drug Targets, 5(3): 327. doi: 10.2174/187152706777452281.

Manufactured in: United Kingdom
Data Sheet Material Safety Data Sheet (MSDS)

Galanin (mouse, rat) is 29 amino acids, 1 less than human galanin. Galanin is a widely distributed neuropeptide in the central nervous, peripheral, and endocrine systems. Galanin interacts with 3 receptor subtypes, GalR1-3. These G protein-coupled receptors are inserted into the plasma membrane. Galanin has a role in energy homeostasis. Central injections of galanin to the amygdala lead to food intake in rats.

Galanin has been shown to inhibit glutamate release from the hippocampus. Glutamate has an excitatory effect in the mechanisms of epileptic seizures; therefore, galanin is considered a possible anticonvulsant.  Galanin receptor agonists with anticonvulsant properties have been developed to help seizures. Galanin has also helped provide evidence of neuronal plasticity and degradation. Galanin has been used extensively for administration to animals in vivo including rats and mice to better understand its role and help treat appetite disorders.

Galanin Mouse, Rat

Cat No.Pack SizePriceQty.
0.5mg£110.00
1mg£170.00
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