Transmembrane Receptors
7-Transmembrane receptors (7-TM receptors), also known as G-protein-coupled receptors, are the largest family of cell surface receptors in the human genome and are integral membrane proteins containing seven membrane-spanning helices. 7-TMs are coupled to intracellular heterotrimeric G proteins, and on ligand binding undergo a conformational change which is transmitted to the G protein.
7-TM receptors are activated by a wide variety of ligands such as nucleotides, peptides, amines, Ca2+ and photons, and are classed into 6 groups – Class A, rhodopsin-like, Class B, the secretin receptor family, Class C, metabotropic glutamate receptors, Class D, fungal mating pheromone receptors, Class E, cyclic AMP receptors and Class F, the frizzled/smoothened receptors.
Mutations in GPCR can cause acquired and inherited diseases such as retinitis pigmentosa, hypo- and hyperthyroidism, nephrogenic diabetes insipidus, fertility disorders, and cancer but due to their large number, widespread distribution and important roles in cell physiology and biochemistry, 7-TM’s have an important role in human medicine and are the target of around half of all modern medicinal drugs.
Showing 129–144 of 150 results
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PAR-1 agonist/ TRAP6TFLLR-amide
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PAR-1 AntagonistYFLLRNP-acid
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PAR-2 agonistSLIGRL-amide
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PAR-2 Agonist amideX-F-[Cha]-[Cha]-RKPNDK-amide
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PAR-2 receptor agonistSLIGKV-amide
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PAR-3 Agonist (Human)TFRGAP-amide
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PAR-3 Agonist (Mouse)SFNGGP-amide
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PAR-4 Agonist (Human)GYPGQV-amide
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PMX 205XPAWR-acid (lactam bridge: Orn1 - Arg5)
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PMX 53
Ac-F-OP-[D-Cha]-WR
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Pro-BNP (47-76)PTGVWKSREVATEGIRGHRKMVLYTLRAPR-acid
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PTH (1-13) HumanSVSEIQLMHNLGK-acid
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PTH (1-34) humanSVSEIQLMHNLGKHLNSMERVEWLRKKLQDVHNF-acid
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PTH (13-34) HumanKHLNSMERVEWLRKKLQDVHNF-acid
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Ser3-n-octanoyl Ghrelin-[Cys(AF647)] Human
GSS(n-octanoyl)-FLSPEHQRVQQRKESKKPPAKLQPR-[Cys(AF647)]-amide
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Sialokinins INTGDKFYGLM-amide
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