PTH (1-34) human SVSEIQLMHNLGKHLNSMERVEWLRKKLQDVHNF-acid
Biologically active peptide fragment of parathyroid hormone (PTH)
Catalogue number crb1000854 Molecular Weight 4115.1 Sequence (one letter code) SVSEIQLMHNLGKHLNSMERVEWLRKKLQDVHNF-acid Sequence (three letter code) H-Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg- Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-OH Aliase PTH 1-34, Parathyroid Hormone 1-34 Purity >95% Storage -20°C References
Lee et al (2014) Parathyroid hormone 1-34 enhances extracellular matrix deposition and organization during flexor tendon repair. J. Orthop. Res. 33(1) 17 PMID: 25266795
Nikitovic et al (2016) Parathyroid hormone/parathyroid hormone-related peptide regulate osteosarcoma cell functions: Focus on the extracellular matrix (Review). Oncol. Rep. 36(4) 1787 PMID: 27499459
Manufactured in: United Kingdom
PTH 1-34, is a biologically active peptide fragment of parathyroid hormone (PTH). PHT 1-34 has been shown to enhance bone fracture healing by promoting osteogenesis. PTH 1-34 also has chondrogenic properties.
PTH is an 84-amino-acid polypeptide hormone (PTH 1-84) which is secreted by the parathyroid glands along with its fragments (such as PTH 1-34 and PTH 7-84). PTH increases calcium and decrease phosphate levels in the blood and the abundance of PTH-derived peptides is regulated by blood calcium levels. PTH inhibits the bone growth-promoting activity of osteoblasts and induces osteoclasts to resorb bone and release calcium and phosphate ions into the blood. PTH binds to and activates the receptor parathyroid hormone receptor 1 (PTHR1). PTHR1 is a G-protein-coupled receptor (GPCR) which regulates mineral ion homeostasis, bone turnover and skeletal development.