PAR-1 agonist/ TRAP6 TFLLR-amide

  • Description

  • Application Data

Description

Representing the activating sequence of the “tethered ligand” of protease cleaved PAR-1; activates PAR-1 with high selectivity

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Application Data

Catalogue number crb1000217
Molecular Weight 647.8
Sequence (one letter code) TFLLR-amide
Sequence (three letter code)

H-Thr-Phe-Leu-Leu-Arg-NH2

Aliase PAR-1 agonist
Purity >95%
Storage -20°C
References

Zhang et al (2014) Evaluation on Potential Contributions of Protease Activated Receptors Related Mediators in Allergic Inflammation. Mediators Inflamm. 2014 1 PMID: 24876677

Manufactured in: United Kingdom
Data Sheet Material Safety Data Sheet (MSDS)

Protease activated receptors (PARs) are a distinctive four-member family of seven transmembrane G protein-coupled receptors (GPCRs) widely expressed in inflammatory cells. PARs are cleaved by certain serine proteases to expose a tethered ligand domain, this ligand domain then binds to and activates the receptors to initiate multiple signalling cascades. These PAR-activating proteases therefore represent PAR agonists. This PAR-1 agonist peptide represents the sequence of the “tethered ligand” and is therefore capable of activating the receptor independently of N-terminal proteolysis. TFLLR-NH2 is more selective to PAR-1 than the PAR-1 agonist SFLLRN-NH2.

Activation of PAR-1 induces platelet aggregation and IL-6 release from monocytes and T cells, as well as several other cellular pathways including those involved in allergic inflammation, neurogenic inflammation and the potentiation of NMDA receptor activity in the hippocampus

PAR-1 agonist/ TRAP6

Cat No.Pack SizePriceQty.
0.5mg£85.00
1mg£110.00
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