Transmembrane Receptors
7-Transmembrane receptors (7-TM receptors), also known as G-protein-coupled receptors, are the largest family of cell surface receptors in the human genome and are integral membrane proteins containing seven membrane-spanning helices. 7-TMs are coupled to intracellular heterotrimeric G proteins, and on ligand binding undergo a conformational change which is transmitted to the G protein.
7-TM receptors are activated by a wide variety of ligands such as nucleotides, peptides, amines, Ca2+ and photons, and are classed into 6 groups – Class A, rhodopsin-like, Class B, the secretin receptor family, Class C, metabotropic glutamate receptors, Class D, fungal mating pheromone receptors, Class E, cyclic AMP receptors and Class F, the frizzled/smoothened receptors.
Mutations in GPCR can cause acquired and inherited diseases such as retinitis pigmentosa, hypo- and hyperthyroidism, nephrogenic diabetes insipidus, fertility disorders, and cancer but due to their large number, widespread distribution and important roles in cell physiology and biochemistry, 7-TM’s have an important role in human medicine and are the target of around half of all modern medicinal drugs.
Showing 1–16 of 150 results
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(Ala11, D-Leu15)-Orexin B human
RSGPPGLQGRAQRL-(D-Leu)-QASGNHAAGILTM-amide
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(D-Pro⁷)-Angiotensin I/II (1-7)
DRVYIHp-acid
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(Des-octanoyl)-Ghrelin Human
GSSFLSPEHQRVQQRKESKKPPAKLQPR-acid
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[5-FAM]-C7
[5-FAM]-MHTAPGWGYRLS-acid
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[5-FAM]-Galanin (2-30)-[Cys] (Human)
[5-FAM]-WTLNSAGYLLGPHAVGNHRSFSDKNGLTS-[C]-amide
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[5-FAM]-GLP-1
[5-FAM]-HDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGR-amide
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[5-FAM]-GLP-1 (7-36)
[5-FAM]-HAEGTFTSDVSSYLEGQAAKEFIAWLVKGR-amide
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[5-FAM]-PTH (1-34)[5-FAM]-SVSEIQLMHNLGKHLNSMERVEWLRKKLQDVHNF-acid
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[5-FAM]-Substance P
[5-FAM]-RPKPQQFFGLM-NH2
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[Azhx]-ANP (Human)[Azhx]-SLRRSSC*FGGRMDRIGAQSGLGC*NSFRY-acid
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[Biotin]-GLP-1
[Biotin]-HDEFERHAEGTFTSDVSSYLEGQAAKEFIA-W-LVKGR-amide
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[Cys]-Exendin 4
[C]-HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-amide
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[Cys]-Galanin (1-30) Human
[Cys]-GWTLNSAGYLLGPHAVGNHRSFSDKNGLTS-acid
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[Pyr]-Apelin-13
[Pyr]-RPRLSHKGPMPF-acid
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