Transmembrane Receptors
7-Transmembrane receptors (7-TM receptors), also known as G-protein-coupled receptors, are the largest family of cell surface receptors in the human genome and are integral membrane proteins containing seven membrane-spanning helices. 7-TMs are coupled to intracellular heterotrimeric G proteins, and on ligand binding undergo a conformational change which is transmitted to the G protein.
7-TM receptors are activated by a wide variety of ligands such as nucleotides, peptides, amines, Ca2+ and photons, and are classed into 6 groups – Class A, rhodopsin-like, Class B, the secretin receptor family, Class C, metabotropic glutamate receptors, Class D, fungal mating pheromone receptors, Class E, cyclic AMP receptors and Class F, the frizzled/smoothened receptors.
Mutations in GPCR can cause acquired and inherited diseases such as retinitis pigmentosa, hypo- and hyperthyroidism, nephrogenic diabetes insipidus, fertility disorders, and cancer but due to their large number, widespread distribution and important roles in cell physiology and biochemistry, 7-TM’s have an important role in human medicine and are the target of around half of all modern medicinal drugs.
Showing 49–64 of 150 results
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ANP (7–20)CFGGRMDRIGAQSG-acid
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ANP (9–22)GGRMDRIGAQSGLG-acid
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ANP 1-28 HumanSLRRSSCFGGRMDRIGAQSGLGCNSFRY-acid (Disulphide bridging Cys7,Cys23)
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Apelin (65-76), human
QRPRLSHKGPMP-acid
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Apelin 13 dual Heavy
QR-[U-13C5,15N-Pro]-R-[U-13C6,15N-Leu]-SHKGPMPF-acid
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Apelin-17 (human, bovine)
KFRRQRPRLSHKGPMPF-acid
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Apelin-36 Human
LVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF-acid
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AYPGFK Protease-Activated Receptor-4 (PAR-4)AYPGKF-amide
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BAM (8-22)VGRPEWWMDYQKRYG-acid
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BIM 187
fQWAVGHLL-amide
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Biotin Substance P
BIOTIN-RPKPQQFFGLM-NH2
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Biotin-ACTH (1-39) HumanBiotin-SYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEF-acid
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Biotin-GLP-1 (7-36)
[Biotin]-HAEGTFTSDVSSYLEGQAAKEFIAWLVKGR-amide
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Biotinylated L57
[Cys(Biotin)]-TWPKHFDKHTFYSILKLGKH-acid
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BNP (18-27) LightISSSSGLGCK-acid
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BNP-32 humanSPKMVQGSGCFGRKMDRISSSSGLGCKVLRRH-acid
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