BAM (8-22) VGRPEWWMDYQKRYG-acid
Description
Application Data
Description
-
BAM (8-22), the Bovine adrenal medulla 8-22 peptide can induce what is known as the ‘itching’ or ‘scratching’ response through activating the G-protein coupled receptor MRGPRX1.
Application Data
-
Data Sheet Material Safety Data Sheet (MSDS)Catalogue number crb1000218 Molecular Weight 1971.2 Sequence (one letter code) VGRPEWWMDYQKRYG-acid Sequence (three letter code) H-Val-Gly-Arg-Pro-Glu-Trp-Trp-Met-Asp-Tyr-Gln-Lys-Arg-Tyr-Gly-OH Molecular Weight 1971.2 Purity >95% Storage -20°C References Sikand et al (2011) BAM8–22 Peptide Produces Itch and Nociceptive Sensations in Humans Independent of Histamine Release. J. Neurosci. 31(20) 7563 PMID: 21593341
Sanjel et al (2019) BAM 8-22 and its receptor MRGPRX1 may attribute to cholestatic pruritus. Sci. Rep. 9 10888 PMID: 31350433
BAM (8-22), the Bovine adrenal medulla 8-22 peptide is synthesised from proekephalin after it has undergone proteolytic cleavage. It can induce what is known as the ‘itching’ or ‘scratching’ response through activating, using an opioid independent mechanism, the G-protein coupled receptor MRGPRX1. This subsequently activates the Gαq/11 pathway and the cation channel TRPA1 histamine independent itch pathways.
It is believed that BAM 8-22 can contribute to chronic itching in diseases such as cholestasis-related pruritus, in which patients are commonly diagnosed as having a reduction in bile flow.