Cyclo(-RGDfK) Cyclo(-RGDfK)

  • Description

  • Application Data


Cyclo(-RGDfK) is a cyclic derivative of RGD, and a potent and selective inhibitor of the αvβ3 integrin receptor.

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Application Data

Catalogue number crb1001046
Molecular Weight 603.3
Sequence (one letter code) Cyclo(-RGDfK)
Sequence (three letter code)


Modifications where f is D-phenylalanine
Purity >95%
Storage -20°C

Dai et al (2000) An improved synthesis of a selective αvβ3-integrin antagonist cyclo(-RGDfK-). Tetrahedron Letters 41 (33) 6295

Manufactured in: United Kingdom
Data Sheet Material Safety Data Sheet (MSDS)

The cyclic pentapeptide cyclo(-Arg-Gly-Asp-d-Phe-Lys) is a highly potent and selective inhibitor for the αvβ3integrin receptor. A related compound, cyclo(-Arg-Gly-Asp-d-Phe-Val), is a promising anticancer drug candidate; it inhibits angiogenesis and induces apoptosis in vascular cells.
Cyclic RGD-containing peptides are selective antagonists of integrins, proteins that play important roles in cell-cell and cell-matrix interactions. In a suitably labelled form, these peptides may serve as useful tools for diagnostic imaging and peptide targeted therapy of some types of cancer.


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