Anti-phospho-TDP-43 (pS409/pS410) antibody

  • Description

  • Application Data

Description

An antibody against TAR DNA binding protein 43 (TDP-43) phosphorylated at serines 409 and 410. TDP-43 binds RNA and is associated with neurodegenerative disorders.

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Application Data

Catalogue number crb2005319
Antibody Anti-phospho-TDP-43 (pS409/pS410) antibody
Antigen Peptide KLH conjugated synthetic peptide crb1200552
Protein ID UniProtKB: Q13148
Aliases TAR DNA-binding protein 43, TARDBP, TDP43
Cross-Reactivity Human
Target Protein Species Human
Host Species Anti-Rabbit
Antibody Type Polyclonal
Concentration N00 Glycine 1mg/ml, M100 Glycine 0.4mg/ml
Validation ELISA (1:1000), WB (0.2 µg/mL)
Target phosphorylated TDP-43 (pS409/pS410)
Storage Stabilisers The product should be stored at -20°C for for short term storage and long term storage. Avoid repeated freeze/ thaw cycles.
Family heterogeneous nuclear ribonucleoprotein (hnRNP) family
Specificity Protein
Post-translational Modification Phosphorylation
Storage The product should be stored at -20°C for for short term storage and long term storage. Avoid repeated freeze/ thaw cycles.
References

Jo et al., (2020). The role of TDP-43 propagation in neurodegenerative diseases: integrating insights from clinical and experimental studies. Exp Mol Med 52: 1652. Doi: 10.1038/s12276-020-00513-7.

Prasad et al., (2019). Molecular mechanisms of TDP-43 misfolding and pathology in amyotrophic lateral sclerosis. Front. Mol. Neurosci., 12: 25. doi: 10.3389/fnmol.2019.00025.

Material Safety Data Sheet (MSDS)

TAR DNA binding protein 43 (TDP-43) is a highly conserved protein that binds RNA via its two RNA recognition motifs RRM1 and RRM2, thereby regulating RNA processing. Binding regulates mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3’UTR leading to poly(A) tail deadenylation and thus, shortening.

TDP-43 aggregates are linked to numerous neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), Alzheimer’s disease (AD), and limbic predominant age-related TDP-43 encephalopathy (LATE).

This TDP-43 antibody is raised against the phosphorylated form at serines 409 and 410, this modification is associated with the pathological aggregated TDP-43. We also have an antibody available for the unphosphorylated form of TDP-43.

Anti-phospho-TDP-43 (pS409/pS410) antibody

Cat No.Pack SizePriceQty.
20µg£170.00
50µg£250.00
20µg£170.00
50µg£250.00
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