Antibody raised against VMP1, an endoplasmic reticulum (ER) transmembrane protein used lipid in homeostasis and regulation of autophagy though involvement in autophagosome biogenesis.
Catalogue number crb2005669 Antibody Anti-VMP1 antibody Antigen Peptide KLH conjugated synthetic peptide crb1200878e Protein ID Q96GC9 VMP1 Aliases Vacuole membrane protein 1,Transmembrane protein 49 Host Species Rabbit Antibody Type Polyclonal Concentration 0.5mg/ml Glycine (R1G), 0.25mg/ml Glycine (R2G) Target VMP1 Storage Stabilisers The product should be stored at -20°C for short term storage and long term storage. Avoid repeated freeze/ thaw cycles. Family VMP1 family Storage The product should be stored at -20°C for short term storage and long term storage. Avoid repeated freeze/ thaw cycles. References
Molejon, M.I., et al. (2013). The VMP1-Beclin 1 interaction regulates autophagy induction. Scientific Reports, 3(1).
Molejon, M.I., et al. (2013). VMP1 is a new player in the regulation of the autophagy-specific phosphatidylinositol 3-kinase complex activation. Autophagy, 9(6), pp.933–935.
Wang, P., Kou, D. and Le, W. (2020). Roles of VMP1 in Autophagy and ER–Membrane Contact: Potential Implications in Neurodegenerative Disorders. Frontiers in Molecular Neuroscience, 13.
Vacuole membrane protein 1 (VMP1) is an endoplasmic reticulum (ER) transmembrane protein, associated with a range of human diseases. Best known for its involvement in diseases such as pancreatitis and Alzheimer’s, VMP1 causes autophagy of cells when it is overexpressed. Through its binding to Beclin1, VMP1 is a key positive regulator of autophagy and is involved in the process of autophagosome generation. However, overexpression of VMP1 can form an excess of complexes, leading to excessive autophagosome generation; this causes the death of the cell regardless of the conditions the cell is under, be that favourable or adverse.
The ER is where most of the biosynthesis of structures withing a cell takes place, with VMP1 being necessary in secretion of lipoproteins and autophagosomes from the ER into the cell matrix. Through interactions with BECN1 and ATP2A2, VMP1 controls the dissociation of autophagosomes from the ER, and plays a part in intracellular communication with other organelles.
VMP1 has the potential to be used in novel cancer treatments, through its involvement in autophagy of specific cellular components; however more research into this application is needed.