Anti-CYR61 antibody

  • Description

  • Application Data


An antibody raised against Cysteine-rich angiogenic inducer 61 (CYR61), a protein with various roles in growth-promoting activities.

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Application Data

Catalogue number crb2005678
Antibody Anti-CYR61 antibody
Antigen Peptide KLH conjugated synthetic peptide crb1200887
Protein ID UniProt KB - O00622
Aliases CCN family member 1, Cellular communication network factor 1, Cysteine-rich angiogenic inducer 61, Insulin-like growth factor-binding protein 10 (IBP-10; IGF-binding protein 10; IGFBP-10), Protein CYR61, Protein GIG1, CCN1, GIG1
Cross-Reactivity Human
Host Species Rabbit
Antibody Type Polyclonal
Concentration 0.5 mg/mL Glycine (R1G), 0.5 mg/mL Glycine (R2G)
Target CYR61
Family CCN family
Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/thaw cycles.

Adams et al., (2018). Matricellular Proteins: Functional Insights From Non-mammalian Animal Models. Curr. Top. Dev. Biol., 130: 39. doi: 10.1016/bs.ctdb.2018.02.003.

Antonicelli, F., & Hornebeck, W. (2014). Matrix Metalloproteinases and Skin Inflammaging. In Inflammation, Advancing Age and Nutrition (pp. 255). Academic Press. doi: 10.1016/B978-0-12-397803-5.00021-6.

Fan et al., (2019). Cysteine-rich 61 (Cyr61): a biomarker reflecting disease activity in rheumatoid arthritis. Arthritis. Res. Ther., 21(1): 123.  doi: 10.1186/s13075-019-1906-y.

Data Sheet Data Sheet Material Safety Data Sheet (MSDS)

Cysteine-rich angiogenic inducer 61 (CYR61) is a secreted protein belonging to the Cellular communication network (CCN) family of polypeptides with four known domains. CYR61 is activated transcriptionally by growth factors and agonists through the G-protein coupled receptor pathway and interacts with herapin sulphate proteoglycan and integrins alpha-3 and alpha-5.

Interaction with integrins aid CYR61 in promoting cell adhesion, cell migration and cell proliferation; the protein also has known roles in chemotaxis, extracellular matrix formation and angiogenesis. Elevated levels of CYR61 are observed in diseases associated with chronic inflammation, including rheumatoid arthritis and various forms of cancer, due to its part in inducing tumour growth, allowing the protein to function as a biomarker of disease activity.

Anti-CYR61 antibody

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