An antibody raised against Mas-related G protein-coupled receptor Member E (mrgpre), a receptor linked to nociceptor function including development, sensation and pain modulation.
Catalogue number crb2005686 Antibody Anti-Mrgpre antibody Antigen Peptide KLH conjugated synthetic peptide crb1200895 Protein ID UniProtKB - Q7TN40 Aliases Mas-related G-protein coupled receptor member E, Mrgpre, Mrge Cross-Reactivity Rat Host Species Rabbit Antibody Type Polyclonal Concentration 2.0 mg/ml Glycine (R1G), 0.5 mg/mL Glycine (R2G), 0.5 mg/mL TEA (R2T) Target Mrgpre Family G-protein coupled receptor 1 family (Mas subfamily) Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/thaw cycles. References
Green (2021). The Role of Mrgprs in Pain. Neurosci. Letters 744:135544. doi: 10.1016/j.neulet.2020.135544.
Van Remoortel et al., (2016). Elucidating Interactions Between Human Mas-related G-protein Coupled Receptors. FASEB Journal 30(1): 1021. doi: 10.1096/fasebj.30.1_supplement.1021.2.
Mrgpre (MAS-related G protein-coupled receptor Member E) is an orphan receptor protein-coding gene located in the plasma membrane. It is predicted to enable G protein-coupled activity through the G protein-coupled receptor signalling pathway. It is thought to be an integral membrane component, initially characterised in small-diameter nociceptive neurons of dorsal root ganglia (DRG).
Mas-related G protein-coupled receptors are involved in mast cell physiology and nociception, enabling their extensive molecular diversity and regulatory effects, particularly within cellular functioning. Belonging to the G protein-coupled receptor (GPCR) family makes Mrgpre’s important targets in the drug discovery field, specifically in neuro-immune communication and pain management.