An antibody that targets CRTh2 (CD294), a G-protein-coupled receptor expressed preferentially in CD4+ effector Th2 cells.
Catalogue number crb2005685 Antibody Anti-Ptgdr2 antibody Antigen Peptide KLH conjugated synthetic peptide crb1200894 Protein ID UniProtKB - Q6XKD3, Q9Z2J6 Aliases Prostaglandin D2 receptor 2, G protein-coupled receptor 44, Crth2, Gpr44, Chemo-attractant receptor-homologous molecule expressed on Th2 cells Cross-Reactivity Rat, Mouse Host Species Rabbit Antibody Type Polyclonal Concentration 0.5 mg/ml Glycine (R1G), 1.0 mg/mL Glycine (R2G) Target Ptgdr2 Family G-protein coupled receptor 1 family Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/thaw cycles. References
Scott et al., (2018). Activation of Th2 Cells Downregulates CRTh2 Through an NFAT1 Mediated Mechanism. PLoS One, 13(7): e0199156. doi: 10.1371/journal.pone.0199156.
Zhang et al., (2018). PGD2/PTGDR2 Signalling Restricts the Self-Renewal and Tumorigenesis of Gastric Cancer. Stem Cells, 36(7): 990. doi: 10.1002/stem.2821.
Prostaglandin D2 ligand activates G-protein-coupled receptors encoded by Ptgdr2, notably CRTh2, which mediate type 2 cytokine production, apoptosis inhibition and pro-inflammatory chemotaxis of Th2 cells, basophils and eosinophils, making the PGD2-CRTh2 pathway a vital factor in the regulation of allergic inflammation. Single nucleotide polymorphisms within the 3’ UTR of the Ptgdr2 gene have been linked to asthma susceptibility, while Ptgdr2 signalling has been associated with self-renewal limitation of gastric cancer cells.
The prostaglandin D and prostaglandin D2 receptor CRTh2 is a chemoattractant receptor homologue that, along with two of its known isoforms, belongs to the G-protein-coupled leukocyte chemoattractant receptor family. Under PGD2 ligation signals, CRTh2, D-prostanoid (DP1) and thromboxane prostanoid (TP) signals are thought to mediate the biological action of prostaglandin D2 through stimulating calcium release from intracellular stores.