Antibody raised against MAP3K5, serine/threonine protein kinase involved in kinase signalling cascades in the cell.
Catalogue number crb2005629 Antibody Anti-MAP3K5 antibody Antigen Peptide KLH conjugated synthetic peptide crb1200837e Protein ID Q99683 Human MAP3K5, O35099 Mouse Map3k5, D3ZZH6 Rat Map3k5 Aliases Mitogen-activated protein kinase kinase kinase 5, MAPKKK5, MAP3K5, MAP3K5/ASK1, Apoptosis signal-regulating kinase 1, ASK1, MAPK/ERK kinase kinase 5, MEK kinase 5, MEKK 5 Cross-Reactivity Human, Mouse, Rat Target Protein Species Human, Mouse, Rat Host Species Rabbit Antibody Type Polyclonal Concentration 1mg/ml DAB029 Target MAP3K5 Storage Stabilisers The product should be stored at -20°C for short term storage and long term storage. Avoid repeated freeze/ thaw cycles. Post-translational Modification Phosphorylated, Ubiquitinated Storage The product should be stored at -20°C for short term storage and long term storage. Avoid repeated freeze/ thaw cycles. References
Morris et al., (2021). Lifespan extension conferred by mitogen-activated protein kinase kinase kinase 5 (MAP3K5) longevity-associated gene variation is confined to at-risk men with a cardiometabolic disease. Aging (Albany NY). 13(6): 7953. PMID: 33739303
Pressinotti et al., (2009). Differential expression of apoptotic genes PDIA3 and MAP3K5 distinguishes between low- and high-risk prostate cancer. Mol Cancer. 8: 130. PMID: 20035634
Prickett et al., (2014). Somatic mutations in MAP3K5 attenuate its pro-apoptotic function in melanoma through increased binding to Thioredoxin. J Invest Dermatol. 34(2): 452. PMID: 24008424
Mitogen-activated protein kinase kinase kinase 5 is a serine/threonine protein kinase involved in kinase signalling cascades in the cell. MAP3K5 plays an important role in cell differentiation and survival, apoptosis, innate immune and inflammatory responses, and oxidative stress response.
Activated MAP3K5/ASK1 initiates the phosphorylation and activation of several MAP kinase kinases such as MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7, followed by p38 MAPKs and c-jun N-terminal kinases (JNKs), which control the transcription factor activator protein-1 (AP-1).
MAP3K5 can be activated in response to stress signals, ROS; such as H2O2, tumour necrosis factor-α (TNFα) or reduced serum levels. It has been shown that a molecular target of reactive oxygen species (ROS),
Thioredoxin (TXN/Trx), is an inhibitor of MAP3K5.
MAP3K5 plays a role in diseases in which reactive oxygen species (ROS) and/or endoplasmic reticulum stress are causative factors, such as type 2 diabetes, neurodegenerative disorders, cardiovascular diseases, inflammatory diseases, and chronic inflammation-induced carcinogenesis. MAP3K5 may prevent stress-induced disorders and protect from bacterial and viral infection.