Anti-MAP3K5 antibody
Description
Application Data
Description
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An antibody raised against MAP3K5; a serine/threonine protein kinase involved in kinase signalling cascades in the cell with a role in apoptosis, innate immune and inflammatory responses, and oxidative stress response.
Application Data
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Material Safety Data Sheet (MSDS)Catalogue number crb2005630 Antibody Anti-MAP3K5 antibody Antigen Peptide KLH conjugated synthetic peptide crb1200837e Protein ID Q99683 Human MAP3K5, O35099 Mouse Map3k5, D3ZZH6 Rat Map3k5 Aliases Mitogen-activated protein kinase kinase kinase 5, MAPKKK5, MAP3K5, MAP3K5/ASK1, Apoptosis signal-regulating kinase 1, ASK1, MAPK/ERK kinase kinase 5, MEK kinase 5, MEKK 5 Cross-Reactivity Human, Mouse, Rat Target Protein Species Human, Mouse, Rat Host Species Rabbit Antibody Type Polyclonal Concentration 1mg/ml DAB030 Target MAP3K5 Storage Stabilisers The product should be stored at -20°C for short term storage and long term storage. Avoid repeated freeze/ thaw cycles. Post-translational Modification Phosphorylated, Ubiquitinated Storage The product should be stored at -20°C for short term storage and long term storage. Avoid repeated freeze/ thaw cycles. References Morris et al., (2021). Lifespan extension conferred by mitogen-activated protein kinase kinase kinase 5 (MAP3K5) longevity-associated gene variation is confined to at-risk men with a cardiometabolic disease. Aging (Albany NY). 13(6): 7953. PMID: 33739303.
Pressinotti et al., (2009). Differential expression of apoptotic genes PDIA3 and MAP3K5 distinguishes between low- and high-risk prostate cancer. Mol Cancer. 8: 130. PMID: 20035634.
Prickett et al., (2014). Somatic mutations in MAP3K5 attenuate its pro-apoptotic function in melanoma through increased binding to Thioredoxin. J Invest Dermatol. 34(2): 452. PMID: 24008424.
Activated MAP3K5/ASK1 initiates the phosphorylation and activation of several MAP kinase kinases such as MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7, followed by p38 MAPKs and c-jun N-terminal kinases (JNKs), which control the transcription factor activator protein-1 (AP-1).
MAP3K5 can be activated in response to stress signals, ROS; such as H2O2, tumour necrosis factor-α (TNFα) or reduced serum levels. It has been shown that a molecular target of reactive oxygen species (ROS),Thioredoxin (TXN/Trx), is an inhibitor of MAP3K5.
MAP3K5 plays a role in diseases in which reactive oxygen species (ROS) and/or endoplasmic reticulum stress are causative factors, such as type 2 diabetes, neurodegenerative disorders, cardiovascular diseases, inflammatory diseases, and chronic inflammation-induced carcinogenesis. MAP3K5 may prevent stress-induced disorders and protect from bacterial and viral infection.