Alexa Fluor® 488 Anti-KA1 antibody
Description
Application Data
Description
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Recognises KA1, a kainate glutamate receptor involved in memory and behaviour. Antibody is conjugated to Alexa Fluor® 488 fluorescent dye
Application Data
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Data Sheet Material Safety Data Sheet (MSDS)Catalogue number crb2115050e Antibody Alexa Fluor® 488 Anti-KA1 antibody Antigen Peptide KLH conjugated synthetic peptide crb1200337e Protein ID UniProtKB - Q01812 Aliases Glutamate receptor ionotropic, kainate 4, Grik4, GluK4, KA1, Glutamate receptor KA-1 Cross-Reactivity Mouse, Rat Target Protein Species Mouse, Rat Host Species Anti-Rabbit Antibody Type Polyclonal Label Labelled with Alexa Fluor® 488 under optimal conditions. Ex: 495nm Em:519nm Concentration 0.19mg/mL Validation ELISA Target KA1 Storage Stabilisers Supplied in PBS containing 0.01% sodium azide. The product should be stored undiluted and protected from prolonged exposure to light. Short term storage between 2-8°C and long term storage below -20°C. Family Glutamate-gated ionic channel family Specificity Protein Storage Supplied in PBS containing 0.01% sodium azide. The product should be stored undiluted and protected from prolonged exposure to light. Short term storage between 2-8°C and long term storage below -20°C. Citations Gauthier, S., Van Haaften, E., Cherbas, L., Cherbas, P. and Hewes, R. (2012). Cryptocephal, the Drosophila melanogaster ATF4, Is a Specific Coactivator for Ecdysone Receptor Isoform B2. PLoS Genet, 8(8), e1002883. PMID: 22912598
Hewes RS1, Schaefer AM, Taghert PH. (2000). The cryptocephal gene (ATF4) encodes multiple basic-leucine zipper proteins controlling molting and metamorphosis in Drosophila. Genetics. 155(4), 1711-1723. PMID: 10924469
References Gauthier, S., Van Haaften, E., Cherbas, L., Cherbas, P. and Hewes, R. (2012). Cryptocephal, the Drosophila melanogaster ATF4, Is a Specific Coactivator for Ecdysone Receptor Isoform B2. PLoS Genet, 8(8), e1002883. PMID: 22912598
Hewes RS1, Schaefer AM, Taghert PH. (2000). The cryptocephal gene (ATF4) encodes multiple basic-leucine zipper proteins controlling molting and metamorphosis in Drosophila. Genetics. 155(4), 1711-1723. PMID: 10924469
Glutamate is the principal excitatory neurotransmitter in the central nervous system (CNS), and imbalances in glutamatergic transmission have profound behavioural and physiological consequences. KA1 is a kainate receptor, which are atypical members of the glutamate receptor family able to signal through both ionotropic and metabotropic pathways. KA1 plays a role in memory and behaviour, and aberrant KA1 expression is seen in neurodegeneration, schizophrenia and bipolar disorder.
The KA1 subunit shows very limited and well-defined expression in just a few neuronal cell types after birth. In the hippocampus KA1 mRNA is expressed at high levels in the CA3 pyramidal neurons and at very low levels in granule cells in the dentate gyrus. In all other neurons in the hippocampus, KA1 is absent.
This antibody is conjugated to Alexa Fluor® 488. Alexa Fluor® 488 is a popular bright green fluorescent dye with high pH-stability.