Temporin B
LLPIVGNLLKSLL-amide
Description
Application Data
Description
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Temporin B is an antimicrobial peptide (AMP) with activity against Gram-positive and Gram-negative pathogens plus antiviral and antifungal activity.
Application Data
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Data Sheet Data Sheet Material Safety Data Sheet (MSDS)Catalogue number crb1001663 Molecular Weight 1390.9 Sequence (one letter code) LLPIVGNLLKSLL-amide
Sequence (three letter code) H-Leu-Leu-Pro-Ile-Val-Gly-Asn-Leu-Leu-Lys-Ser-Leu-Leu-OH
Purity >95% Storage This material should be stored below 0 degrees C Citations Manzo et al., (2019). Minor sequence modifications in temporin B cause drastic changes in antibacterial potency and selectivity by fundamentally altering membrane activity. Sci Rep, 9: 1385. doi: 10.1038/s41598-018-37630-3.
References Kakar et al., (2022). The Membrane Activity of the Amphibian Temporin B Peptide Analog TB_KKG6K Sheds Light on the Mechanism That Kills Candida albicans. Mpshere, 7(5): e00290. doi: 10.1128/msphere.00290-22.
Marcocci et al., (2018). The Amphibian Antimicrobial Peptide Temporin B Inhibits In Vitro Herpes Simplex Virus 1 Infection. Antimicrob. Agents Chemother., 62(5): e02367. doi: 10.1128/AAC.02367-17.
Manufactured in: United Kingdom Temporins are mainly active against Gram-positive bacteria, with low minimum inhibitory concentration (MIC) values. Temporin B is part of the temporin family and contains the conserved signature sequence with weak cationic charge. Temporin AMP activity against bacteria and mycetes is well characterised, with some having antiviral activity against viruses. Temporin B shows activity against herpes simplex virus (HSV-1).
Temporin B is a viable AMP for therapeutics, showing no hemolytic or cytotoxicity to mammalian cells in vitro. Analogues have been generated to amplify the activity as an AMP, antiviral or antifungal such as against HSV-1 and Candida albicans.