Antibody raised against ICOS, a protein used to enhance all basic T-cell responses to foreign antigens, necessary for efficient interactions between B and T-cellsand normal antibody response to T-cell dependant antigens.
Catalogue number crb2005663 Antibody Anti-ICOS antibody Antigen Peptide KLH conjugated synthetic peptide crb1200872e Protein ID Q9Y6W8 ICOS Aliases Inducible T-cell costimulator, Activation-inducible lymphocyte immunomediatory molecule, CD278 Host Species Rabbit Antibody Type Polyclonal Concentration 1.0mg/ml Glycine (R2G), 0.5mg/ml TEA (R2T) Target ICOS Storage Stabilisers The product should be stored at -20°C for short term storage and long term storage. Avoid repeated freeze/ thaw cycles. Storage The product should be stored at -20°C for short term storage and long term storage. Avoid repeated freeze/ thaw cycles. References
Hutloff, A. et al. (1999). ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. Nature, 397(6716), pp.263–266.
Rigas, D., et al. (2017). Type 2 innate lymphoid cell suppression by regulatory T cells attenuates airway hyperreactivity and requires inducible T-cell costimulator–inducible T-cell costimulator ligand interaction. Journal of Allergy and Clinical Immunology, 139(5), pp.1468-1477.e2.
Yu, D., et al. (2007). Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA. Nature, 450(7167), pp.299–303.
Inducible T-cell Costimulator (ICOS) belongs to the CD28 and CTLA-4 family of cell surface receptors, an important family in the regulation of the immune system. It is a homodimer, playing a key role in cell-cell communication and immune response. ICOS is an activation dependant, T-cell specific cell surface molecule; it enhances all basic T-cell responses to foreign antigens, including proliferation, secretion of lymphokines and uptake regulation of molecules that mediate cell-cell communication. This makes ICOS essential for efficient interaction of T and B- cells, required for an effective antigen-specific immune response and for the normal immune response of antibodies to T-cell dependant antigens.
Standard immune responses are normally targeted against microbial pathogens, rather than self-cells. Overexpression of ICOS due to disfunctions in in signalling pathways preventing ligand interactions can increase autoimmunity. ICOS-ICOS-ligand cell contact is necessary for not only enhancement of immune response, but for immune response to occur normally and without autoimmunity.