B-Raf peptide
Description
Application Data
Description
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Antigenic peptide of B-raf kinase, a serine/threonine kinase and proto-oncogene involved in directing cell growth
Application Data
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Data Sheet Material Safety Data Sheet (MSDS)Catalogue number crb1200381 Antibody B-Raf peptide Antigen Peptide B-Raf peptide Protein ID UniProtKB - P15056 Aliases Serine/threonine-protein kinase B-raf, Proto-oncogene B-Raf, BRAF, RAFB1, P94, V-Raf Murine Sarcoma Viral Oncogene Homolog B Cross-Reactivity Human, rat, mouse, chicken Target Protein Species Human, rat, mouse, chicken Storage Stabilisers -20°C Specificity Protein Storage -20°C Citations Eisenhardt, A., Sprenger, A., Röring, M., Herr, R., Weinberg, F., Köhler, M., Braun, S., Orth, J., Diedrich, B., Lanner, U., Tscherwinski, N., Tscherwinski, S., Schuster, S., Dumaz, N., Schmidt, E., Baumeister, R., Schlosser, A., Dengjel, J. and Brummer, T. (2016). Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles. Oncotarget, 7(18). PMID: 27034005
Li, Y., Takahashi, M. and Stork, P. (2013). Ras-mutant Cancer Cells Display B-Raf Binding to Ras That Activates Extracellular Signal-regulated Kinase and Is Inhibited by Protein Kinase A Phosphorylation. J Biol Chem, 288(38), 27646-27657. PMID: 23893412
References Eisenhardt, A., Sprenger, A., Röring, M., Herr, R., Weinberg, F., Köhler, M., Braun, S., Orth, J., Diedrich, B., Lanner, U., Tscherwinski, N., Tscherwinski, S., Schuster, S., Dumaz, N., Schmidt, E., Baumeister, R., Schlosser, A., Dengjel, J. and Brummer, T. (2016). Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles. Oncotarget, 7(18). PMID: 27034005
Li, Y., Takahashi, M. and Stork, P. (2013). Ras-mutant Cancer Cells Display B-Raf Binding to Ras That Activates Extracellular Signal-regulated Kinase and Is Inhibited by Protein Kinase A Phosphorylation. J Biol Chem, 288(38), 27646-27657. PMID: 23893412
B-Raf (BRAF) is a raf-family serine/threonine kinase and proto-oncogene involved in directing cell growth. The Raf kinases are subject to a complex activation process that integrates various protein-protein and protein–lipid interactions and positive as well as negative phosphorylation events. The Ras/Raf/mitogen-activated/extracellular-regulated kinase (MEK)/extracellular signal regulated kinase (ERK) pathway plays a pivotal role in controlling proliferation, survival and differentiation of metazoan cells.
B-Raf, the most potent kinase of the family, plays an important role in various developmental processes. B-Raf is also the most frequently mutated kinase in cancer, making it an important target for cancer treatment, especially in melanoma and hairy cell leukaemia. BRAF mutations are also found in the neuro-cardio-facio-cutaneous syndromes or RASopathies.