B-Raf peptide

  • Description

  • Application Data

Description

Antigenic peptide of B-raf kinase, a serine/threonine kinase and proto-oncogene involved in directing cell growth

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Application Data

Catalogue number crb1200381
Antibody B-Raf peptide
Antigen Peptide B-Raf peptide
Protein ID UniProtKB - P15056
Aliases Serine/threonine-protein kinase B-raf, Proto-oncogene B-Raf, BRAF, RAFB1, P94, V-Raf Murine Sarcoma Viral Oncogene Homolog B
Cross-Reactivity Human, rat, mouse, chicken
Target Protein Species Human, rat, mouse, chicken
Storage Stabilisers -20°C
Specificity Protein
Storage -20°C
Citations

Eisenhardt, A., Sprenger, A., Röring, M., Herr, R., Weinberg, F., Köhler, M., Braun, S., Orth, J., Diedrich, B., Lanner, U., Tscherwinski, N., Tscherwinski, S., Schuster, S., Dumaz, N., Schmidt, E., Baumeister, R., Schlosser, A., Dengjel, J. and Brummer, T. (2016). Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles. Oncotarget, 7(18). PMID: 27034005

 

Li, Y., Takahashi, M. and Stork, P. (2013). Ras-mutant Cancer Cells Display B-Raf Binding to Ras That Activates Extracellular Signal-regulated Kinase and Is Inhibited by Protein Kinase A Phosphorylation. J Biol Chem, 288(38), 27646-27657. PMID: 23893412

References

Eisenhardt, A., Sprenger, A., Röring, M., Herr, R., Weinberg, F., Köhler, M., Braun, S., Orth, J., Diedrich, B., Lanner, U., Tscherwinski, N., Tscherwinski, S., Schuster, S., Dumaz, N., Schmidt, E., Baumeister, R., Schlosser, A., Dengjel, J. and Brummer, T. (2016). Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles. Oncotarget, 7(18). PMID: 27034005

 

Li, Y., Takahashi, M. and Stork, P. (2013). Ras-mutant Cancer Cells Display B-Raf Binding to Ras That Activates Extracellular Signal-regulated Kinase and Is Inhibited by Protein Kinase A Phosphorylation. J Biol Chem, 288(38), 27646-27657. PMID: 23893412

Data Sheet Material Safety Data Sheet (MSDS)

B-Raf (BRAF) is a raf-family serine/threonine kinase and proto-oncogene involved in directing cell growth. The Raf kinases are subject to a complex activation process that integrates various protein-protein and protein–lipid interactions and positive as well as negative phosphorylation events. The Ras/Raf/mitogen-activated/extracellular-regulated kinase (MEK)/extracellular signal regulated kinase (ERK) pathway plays a pivotal role in controlling proliferation, survival and differentiation of metazoan cells.

B-Raf, the most potent kinase of the family, plays an important role in various developmental processes. B-Raf is also the most frequently mutated kinase in cancer, making it an important target for cancer treatment, especially in melanoma and hairy cell leukaemia. BRAF mutations are also found in the neuro-cardio-facio-cutaneous syndromes or RASopathies.

B-Raf peptide

Cat No.Pack SizePriceQty.
100µg£85.00
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