GluR2 peptide
Description
Application Data
Description
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Antigenic peptide from the GluR2 subunit of AMPAR
Application Data
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Data Sheet Material Safety Data Sheet (MSDS)Catalogue number crb1200336 Antibody GluR2 peptide Antigen Peptide GluR2 peptide Protein ID UniProtKB - Q14416 Aliases GRIA2, GLUR2, GLURB, GluA2, GluR-K2, HBGR2, glutamate ionotropic receptor AMPA type subunit 2 Cross-Reactivity Rat Target Protein Species Rat Storage Stabilisers -20°C Specificity Protein Storage -20°C Citations Li, D., Byan, H. and Pan, H. (2012). Switch to Glutamate Receptor 2-Lacking AMPA Receptors Increases Neuronal Excitability in Hypothalamus and Sympathetic Drive in Hypertension. J Neurosci, 32(1), 372-380. PMID: 22219297
Wang, M., Li, S., Zhang, H., Pei, L., Zou, S., Lee, F., Wang, Y. and Liu, F. (2012). Direct interaction between GluR2 and GAPDH regulates AMPAR-mediated excitotoxicity. Mol Brain, 5(1), 13. PMID: 22537872
References Li, D., Byan, H. and Pan, H. (2012). Switch to Glutamate Receptor 2-Lacking AMPA Receptors Increases Neuronal Excitability in Hypothalamus and Sympathetic Drive in Hypertension. J Neurosci, 32(1), 372-380. PMID: 22219297
Wang, M., Li, S., Zhang, H., Pei, L., Zou, S., Lee, F., Wang, Y. and Liu, F. (2012). Direct interaction between GluR2 and GAPDH regulates AMPAR-mediated excitotoxicity. Mol Brain, 5(1), 13. PMID: 22537872
The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) is an ionotropic transmembrane receptor for glutamate found throughout the central nervous system (CNS). AMPARs are composed of four types of subunits: GluR1/GluA1, GluR2/GluA2, GluR3/GluA3, and GluA4 (GluRA-D2), which combine to form heterotetramers.
The function of AMPARs is determined by the composition of AMPAR subunits. GluR2-containing AMPARs have little Ca2+ permeability. The GluR2 subunit interacts with several proteins and regulates the lysosomal targeting and degradation of AMPARs.
Defects in expression of GluR2 may be involved to the development of motor neurone disease (MDN/ALS).