Anti-Phospho-GluR2 (pS880) antibody

  • Description

  • Application Data

Description

Recognises the GluR2 subunit of AMPAR with a phosphorylated serine at position 880

See full description

Application Data

Catalogue number crb2005005
Antibody Anti-Phospho-GluR2 (pS880) antibody
Antigen Peptide KLH conjugated synthetic peptide crb1200275e
Protein ID UniProtKB - Q14416
Aliases GRIA2, GLUR2, GLURB, GluA2, GluR-K2, HBGR2, glutamate ionotropic receptor AMPA type subunit 2
Cross-Reactivity Rat
Host Species Rabbit
Antibody Type Polyclonal
Label Unconjugated
Concentration 1mg/ml
Validation 1:1000 (WB), 1:1000 (ELISA)
Target phosphorylated GluR2 (pS880)
Disease Area Neurodegenerative diseases
Post-translational Modification Phosphorylation of Serine 880
Citations

Kohda, K., Kakegawa, W., Matsuda, S., Yamamoto, T., Hirano, H. and Yuzaki, M. (2013). The 2 glutamate receptor gates long-term depression by coordinating interactions between two AMPA receptor phosphorylation sites. PNAS, 110(10), E948-E957. PMID: 23431139

References

Kohda, K., Kakegawa, W., Matsuda, S., Yamamoto, T., Hirano, H. and Yuzaki, M. (2013). The 2 glutamate receptor gates long-term depression by coordinating interactions between two AMPA receptor phosphorylation sites. PNAS, 110(10), E948-E957. PMID: 23431139

Material Safety Data Sheet (MSDS)

The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) is an ionotropic transmembrane receptor for glutamate found throughout the central nervous system (CNS). AMPARs are composed of four types of subunits: GluR1/GluA1, GluR2/GluA2, GluR3/GluA3, and GluA4 (GluRA-D2), which combine to form heterotetramers.

The GluR2 subunit interacts with several proteins and regulates the lysosomal targeting and degradation of AMPARs. Phosphorylation of AMPARs is often implicated in synaptic plasticity and the pathological signalling seen in several disease states. Phosphorylation of GluR2 on serine 880 is involved in changes of synaptic efficacy where it regulates GluR2 synaptic recycling, AMPA signalling strength and plasticity.

Anti-Phospho-GluR2 (pS880) antibody

Cat No.Pack SizePriceQty.
50ug£220.00
20ug£110.00
Bulk Quote