Anti-Phospho-GluR2 (pS880) antibody
Description
Application Data
Description
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Recognises the GluR2 subunit of AMPAR with a phosphorylated serine at position 880
Application Data
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Material Safety Data Sheet (MSDS)Catalogue number crb2005005 Antibody Anti-Phospho-GluR2 (pS880) antibody Antigen Peptide KLH conjugated synthetic peptide crb1200275e Protein ID UniProtKB - Q14416 Aliases GRIA2, GLUR2, GLURB, GluA2, GluR-K2, HBGR2, glutamate ionotropic receptor AMPA type subunit 2 Cross-Reactivity Rat Host Species Rabbit Antibody Type Polyclonal Label Unconjugated Concentration 1mg/ml Validation 1:1000 (WB), 1:1000 (ELISA) Target phosphorylated GluR2 (pS880) Disease Area Neurodegenerative diseases Post-translational Modification Phosphorylation of Serine 880 Citations Kohda, K., Kakegawa, W., Matsuda, S., Yamamoto, T., Hirano, H. and Yuzaki, M. (2013). The 2 glutamate receptor gates long-term depression by coordinating interactions between two AMPA receptor phosphorylation sites. PNAS, 110(10), E948-E957. PMID: 23431139
References Kohda, K., Kakegawa, W., Matsuda, S., Yamamoto, T., Hirano, H. and Yuzaki, M. (2013). The 2 glutamate receptor gates long-term depression by coordinating interactions between two AMPA receptor phosphorylation sites. PNAS, 110(10), E948-E957. PMID: 23431139
The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) is an ionotropic transmembrane receptor for glutamate found throughout the central nervous system (CNS). AMPARs are composed of four types of subunits: GluR1/GluA1, GluR2/GluA2, GluR3/GluA3, and GluA4 (GluRA-D2), which combine to form heterotetramers.
The GluR2 subunit interacts with several proteins and regulates the lysosomal targeting and degradation of AMPARs. Phosphorylation of AMPARs is often implicated in synaptic plasticity and the pathological signalling seen in several disease states. Phosphorylation of GluR2 on serine 880 is involved in changes of synaptic efficacy where it regulates GluR2 synaptic recycling, AMPA signalling strength and plasticity.