Anti-Phospho-GluR2 (pS880) antibody
Recognises the GluR2 subunit of AMPAR with a phosphorylated serine at position 880
Catalogue number crb2005005 Antibody Anti-Phospho-GluR2 (pS880) antibody Antigen Peptide KLH conjugated synthetic peptide crb1200275e Protein ID UniProtKB - Q14416 Aliases GRIA2, GLUR2, GLURB, GluA2, GluR-K2, HBGR2, glutamate ionotropic receptor AMPA type subunit 2 Cross-Reactivity Rat Target Protein Species Rat Host Species Rabbit Antibody Type Polyclonal Label Unconjugated Concentration 1mg/ml Validation 1:1000 (WB), 1:1000 (ELISA) Target phosphorylated GluR2 (pS880) Storage Stabilisers This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/ thaw cycles. Family Glutamate-gated ion channel family Disease Area Neurodegenerative diseases Post-translational Modification Phosphorylation of Serine 880 Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/ thaw cycles. References
Kohda, K., Kakegawa, W., Matsuda, S., Yamamoto, T., Hirano, H. and Yuzaki, M. (2013). The 2 glutamate receptor gates long-term depression by coordinating interactions between two AMPA receptor phosphorylation sites. PNAS, 110(10), E948-E957. PMID: 23431139
The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) is an ionotropic transmembrane receptor for glutamate found throughout the central nervous system (CNS). AMPARs are composed of four types of subunits: GluR1/GluA1, GluR2/GluA2, GluR3/GluA3, and GluA4 (GluRA-D2), which combine to form heterotetramers.
The GluR2 subunit interacts with several proteins and regulates the lysosomal targeting and degradation of AMPARs. Phosphorylation of AMPARs is often implicated in synaptic plasticity and the pathological signalling seen in several disease states. Phosphorylation of GluR2 on serine 880 is involved in changes of synaptic efficacy where it regulates GluR2 synaptic recycling, AMPA signalling strength and plasticity.