TSG101 is a component of the ESCRT-I complex, a regulator of vesicular trafficking process. Ubiquitously expressed, and functions in diverse intracellular processes.
Catalogue number crb2005639 Antibody Anti-TSG101 antibody Antigen Peptide KLH conjugated synthetic peptide crb1200848e Protein ID Q99816 Human TSG101, Q61187 Mouse Tsg101, Q6IRE4 Rat Tsg101 Aliases Tumor susceptibility gene 101 protein, ESCRT-I Complex Subunit TSG101, VPS23, TSG101 Cross-Reactivity Human, Mouse, Rat Target Protein Species Human, Mouse, Rat Host Species Rabbit Antibody Type Polyclonal Concentration 1mg/ml Target TSG101 Storage Stabilisers The product should be stored at -20°C for short term storage and long term storage. Avoid repeated freeze/ thaw cycles. Storage The product should be stored at -20°C for short term storage and long term storage. Avoid repeated freeze/ thaw cycles. References
Ferraiuolo et al., (2020). The Multifaceted Roles of the Tumor Susceptibility Gene 101 (TSG101) in Normal Development and Disease. Cancers (Basel). 12(2): 450. PMID: 32075127
TSG101 is a housekeeping gene expressed in all tissues and cell types, including in 1-cell and 2-cell stage embryos. The highest Tsg101 levels are found in the brain and lactating mammary glands. TSG101 facilitates a variety of molecular and biological processes, including the regulation of transcription, cell proliferation and division. However the best studied role is in ubiquitination and protein sorting.
TSG101 is present within exosomes and plays a role in extracellular vesicle (EV) assembly and release. TSG101 is a member of the class E proteins, a subset of the vacuolar protein sorting proteins (VPS) which form the endosomal sorting complex required for transport I (ESCRT-I). As part of this complex, TSG101 selectively binds ubiquitinated cargo proteins to direct their sorting into multivesicular endosomes. TSG101 is a negative regulator of ubiquitin-mediated protein degradation. The E3 ubiquitin ligases: MDM2, MGRN1 and LRSAM1/TAL control TSG101 levels in mammalian cells.
TSG101 may be involved in diseases like cancer and neurodegeneration. TSG101 is overexpressed in some cancers, including breast, lung, thyroid, ovarian, and colon. Optimal TSG101 levels are also required for heart muscle growth.