Anti-Dixin antibody

  • Description

  • Application Data


An antibody raised against the dixin protein; a positive regulator of the Wnt pathway as well as a regulator of cytoskeleton dynamics and neural development.

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Application Data

Catalogue number crb2005699
Antibody Anti-Dixin antibody
Antigen Peptide KLH conjugated synthetic peptide crb1200908
Protein ID Q155Q3 - UniProtKB
Aliases Dixin, DIXDC1, DIX domain-containing protein 1, Dixdc1, Coiled-coil protein DIX1, Coiled-coil-DIX1, CCD1, KIAA1735
Cross-Reactivity Human, Mouse, Rat
Host Species Rabbit
Antibody Type Polyclonal
Concentration 2mg/ml Glycine (R1G)
Target Dixin
Family DIXDC1 family
Data Sheet Material Safety Data Sheet (MSDS)

Dixin activates DVL2 leading to Wnt3a signalling activation. Dixin was found to be an inhibitory regulator of JNK activity via AXIN1 and DVL2.  A catalogue of evidence suggests dysregulation of DIXDC1 is involved in the progression and development of a wide variety of cancers including acute myeloid leukaemia (AML), gastric, colon, and retinoblastoma. The role between DIXDC1 regulation of the Wnt pathway cancer cells remains unclear.

Dixin also associates with gamma tubulin at the centrosome, phosphorylation of Dixin has been shown to regulate its function in actin and microtubule cytoskeleton dynamics. Evidence suggests that Dixin is associated with chromosome segregation and cell cycle regulation.

Multiple Dixin isoforms have been identified. Mark1 was identified as key to phosphorylating the various isoforms to regulate dendrite and spine development. Autism spectrum disorders variations in DIXDC1 isoform 1 have been linked to impaired phosphorylation and neuronal morphology.

Anti-Dixin antibody

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