An antibody raised against the dixin protein; a positive regulator of the Wnt pathway as well as a regulator of cytoskeleton dynamics and neural development.
Catalogue number crb2005649 Antibody Anti-Dixin antibody Antigen Peptide KLH conjugated synthetic peptide crb1200858e Protein ID Q155Q3 Human DIXDC1, Q80Y83 Mouse Dixdc1 Aliases Dixin, DIXDC1, DIX domain-containing protein 1, Dixdc1, Coiled-coil protein DIX1, Coiled-coil-DIX1, CCD1, KIAA1735 Cross-Reactivity Human, Mouse Target Protein Species Human, Mouse Host Species Rabbit Antibody Type Polyclonal Concentration 1mg/ml Glycine (R1G), 1mg/ml Glycine (R2G) Target Dixin Storage Stabilisers The product should be stored at -20°C for short term storage and long term storage. Avoid repeated freeze/ thaw cycles. Storage The product should be stored at -20°C for short term storage and long term storage. Avoid repeated freeze/ thaw cycles. References
Kwan et al., (2016) DIXDC1 Phosphorylation and Control of Dendritic Morphology Are Impaired by Rare Genetic Variants. Cell Rep. 17(7):1892. PMID: 27829159.
Wu et al., (2009) DIXDC1 co-localizes and interacts with gamma-tubulin in HEK293 cells. Cell Biol. Int. 33(6): 697. DOI:10.1016/j.cellbi.2009.04.001.
Xin et al., (2018) DIXDC1 promotes the growth of acute myeloid leukemia cells by upregulating the Wnt/β-catenin signaling pathway. Biomed. Pharmacother. 107: 1548. DOI: 10.1016/j.biopha.2018.08.144.
Dixin activates DVL2 leading to Wnt3a signalling activation. Dixin was found to be an inhibitory regulator of JNK activity via AXIN1 and DVL2. A catalogue of evidence suggests dysregulation of DIXDC1 is involved in the progression and development of a wide variety of cancers including acute myeloid leukaemia (AML), gastric, colon, and retinoblastoma. The role between DIXDC1 regulation of the Wnt pathway cancer cells remains unclear.
Dixin also associates with gamma tubulin at the centrosome, phosphorylation of Dixin has been shown to regulate its function in actin and microtubule cytoskeleton dynamics. Evidence suggests that Dixin is associated with chromosome segregation and cell cycle regulation.
Multiple Dixin isoforms have been identified. Mark1 was identified as key to phosphorylating the various isoforms to regulate dendrite and spine development. Autism spectrum disorders variations in DIXDC1 isoform 1 have been linked to impaired phosphorylation and neuronal morphology.