Histone H2B peptide
Description
Application Data
Description
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Peptide from histone H2B, one of the four core histone proteins
Application Data
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Data Sheet Material Safety Data Sheet (MSDS)Catalogue number crb1200311 Antibody Histone H2B peptide Antigen Peptide Histone H2B peptide Protein ID UniProtKB - P62807 Aliases Histone H2B type 1-C/E/F/G/I Cross-Reactivity Human, Rabbit, Mouse Target Protein Species Human, Rabbit, Mouse Storage Stabilisers -20°C Specificity Protein Storage -20°C Citations Cole, A., Clifton-Bligh, R. and Marsh, D. (2014). Histone H2B monoubiquitination: roles to play in human malignancy. Endoc-Related Cancer, 22(1), T19-T33. PMID: 24891457
Khan, M., Alam, K., Hassan, S. and Rizvi, M. (2017). Nitration of H2B histone elicits an immune response in experimental animals. Autoimmunity, 50(4), 232-240. PMID: 28737980
Mao, P., Kyriss, M., Hodges, A., Duan, M., Morris, R., Lavine, M., Topping, T., Gloss, L. and Wyrick, J. (2016). A basic domain in the histone H2B N-terminal tail is important for nucleosome assembly by FACT. Nucleic Acids Res, 44(19), 9142–9152. PMID: 27369377
References Cole, A., Clifton-Bligh, R. and Marsh, D. (2014). Histone H2B monoubiquitination: roles to play in human malignancy. Endoc-Related Cancer, 22(1), T19-T33. PMID: 24891457
Khan, M., Alam, K., Hassan, S. and Rizvi, M. (2017). Nitration of H2B histone elicits an immune response in experimental animals. Autoimmunity, 50(4), 232-240. PMID: 28737980
Mao, P., Kyriss, M., Hodges, A., Duan, M., Morris, R., Lavine, M., Topping, T., Gloss, L. and Wyrick, J. (2016). A basic domain in the histone H2B N-terminal tail is important for nucleosome assembly by FACT. Nucleic Acids Res, 44(19), 9142–9152. PMID: 27369377
Antigenic peptide from Histone H2B. H2B. H2B is one of the four core histone proteins which make up the protein core of the nucleosome around which DNA is wound to form the basic unit of chromatin. H2B, like other histone proteins is highly conserved across species with even distantly related species having high levels of sequence homology. Post translational modifications of histones such as H2B by acetylation, phosphorylation and ubiquitination can affect the organisation of the chromatin and gene transcription. There are 16 isoforms of H2B in humans, 13 that are expressed in somatic cells, and 3 that are testis-specific.