An antibody raised against TORC-2; a serine/threonine kinase that has a function in a diverse array of systems including cell growth and metabolism.
Catalogue number crb2005646 Antibody Anti-TORC-2 antibody Antigen Peptide KLH conjugated synthetic peptide crb1200856e Protein ID Q53ET0 Human CRTC2 Aliases CREB-regulated transcription coactivator 2, CRTC2, Transducer of regulated cAMP response element-binding protein 2, Transducer of CREB protein 2, TORC-2 Cross-Reactivity Human Target Protein Species Human Host Species Rabbit Antibody Type Polyclonal Concentration 1mg/ml DAB048 Target TORC-2 Storage Stabilisers The product should be stored at -20°C for short term storage and long term storage. Avoid repeated freeze/ thaw cycles. Family Hominidae Post-translational Modification Phosphorylated, Methylated Storage The product should be stored at -20°C for short term storage and long term storage. Avoid repeated freeze/ thaw cycles. References
Conkright et al., (2003). TORCs: transducers of regulated CREB activity. Mol. Cell. 12(2): 413. PMID: 14536081.
Jansen (2020). mTORC2 Steals the Spotlight. Epilepsy curr. 20(2): 116. PMID: 32100554.
Siu et al., (2006). TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats. J Virol. 80(14): 7052. PMID: 16809310.
The role of TORC-2 has not been as well characterised as its family member TORC-1. TORC-2 is a complex that acts as a transcriptional coactivator for CREB1 enhancing its interaction with TAF4 leading to specific gene induction such as steroidogenic gene, StAR. TORC-2 is also as a coactivator in several pathways including the SIK/TORC signalling pathway plus the LKB1/AMPK/TORC2 signalling regulating gluconeogenesis. Also, it is a coactivator for TAX activation of the human T-cell leukaemia virus type 1 (HTLV-1) long terminal repeats (LTR). It is a potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells.
Dysregulation of TORCs or the PI3K-AKT-mTOR pathway have been linked to numerous neurological diseases termed mTORopathies. Overactivation of mTOR pathways are a known cause of epilepsy, developmental disability, and autism. Due to the numerous functions being uncovered that are exclusive to TORC-2 and the diseases implicated this antibody could be a vital tool to fully establish TORC-2’s functions.