Antibody raised against UCP1; a mitochondrial protein used in adaptive thermogenesis and regulation of energy balance. Functions as long-chain fatty acid and proton symporter, allowing one LCFA & proton through the inner mitochondrial membrane.
Catalogue number crb2005693 Antibody Anti-UCP1 antibody Antigen Peptide KLH conjugated synthetic peptide crb1200902 Protein ID UniProt KB - P25874 Aliases Mitochondrial brown fat uncoupling protein 1, Solute carrier family 25 member 7, Thermogenin, SLC25A7, UCP Cross-Reactivity Human Host Species Rabbit Antibody Type Polyclonal Concentration 0.1 mg/mL TEA (R1T), 1 mg/mL Glycine (R2G), 0.2 mg/mL (R2T) Target UCP1 Family mitochondrial carrier (mc) family Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/thaw cycles.
Mitochondrial brown fat uncoupling protein 1 (UPC1) allows non-shivering thermogenesis to be undertaken in the brown adipose tissue. This occurs due to activation of UPC1 by long chain fatty acids causing an increase in conductance of H+ ions across the inner mitochondrial membrane. This increase in conductance causes brown adipose tissue mitochondria to generate heat, rather than ATP.
When compared with UCP2 and UCP3, UCP1 differs as its expression is positively correlated with metabolic inefficiency, and is increased by cold acclimation. Because of this UCP2/UCP3 cannot be used as UCP1 substitutes, any kind of cold acclimation-induced non-shivering thermogenesis is entirely dependent on the presence of UCP1.