TCO reagents
TCO (trans-cycloctene) reagents are commonly used in catalyst-free protein-protein bioconjugation, labelling live cells and polymer coupling (such as tetrazine hydrogels). The inverse-electron demand Diels-Alder cycloaddition reaction (IEDDA) between TCO compounds and tetrazines produces a conjugate at extremely high rates and selectivity. The water-tolerant IEDDA reaction is then followed by a retro-DA reaction to eliminate Nitrogen gas.
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Sulfo TCO-Maleimide
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TCO Agarose
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TCO-Amine HCl Salt
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TCO-NHS Ester (axial)
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TCO-NHS Ester (equatorial)
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TCO-PEG3-Amine
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TCO-PEG3-Maleimide
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TCO-PEG4-Acid
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TCO-PEG4-NHS Ester
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TCO-PEG4-TFP Ester
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TCO-PNB Ester (equatorial)
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