Extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) are members of the mitogen-activated protein kinase (MAPK) super family that regulate cell proliferation and apoptosis. The 44 kDa ERK1 and 42 kDa ERK2 share 83% amino acid identity with higher homology in the core regions and are expressed in almost all tissues. ERK1/2 are protein-Ser/Thr kinases… Read more »
Posts By: Ling-i Su
Peptide Substrates: Focus on LRRKtide
Mutations in the Leucine-rich repeat kinase-2 (LRRK2) gene have been associated with familial and sporadic Parkinson’s disease (PD), which is the second most common neurodegenerative disorder worldwide after Alzheimer’s. LRRK2 is a multi-domain protein that contains an LRR (leucine rich repeats) motif, a COR (C-terminal of Ras of Complex) domain, a WD40 (Trp-Asp 40) motif… Read more »
Focus on Myelin Oligodendrocyte Glycoprotein (MOG)
Myelin oligodendrocyte glycoprotein (MOG) is a type I integral membrane protein on the extracellular surface of oligodendrocytes in the outermost lamellae of the myelin sheath. MOG can exist as monomeric and dimeric species. Its extracellular localisation facilitates its functions as a homophilic adhesion receptor, where it plays a role in the completion, compaction and maintenance of the… Read more »
Cell Penetrating Peptides: Focus on Arg9
An Introduction to Cell Penetrating Peptides: Due to the hydrophilic nature of the majority of proteins and peptides, they are largely impermeable to cell membranes. Cell Penetrating Peptides (CPP’s) therefore possess a pivotal role in terms of their ability to successfully facilitate cellular uptake of molecular cargos across the cell or plasma membrane. They typically… Read more »
Phospho-Specific Antibodies: Focus on CDK1
Cyclin D1 is a key regulator of cell proliferation as it links the extracellular signaling environment to cell cycle progression. Cyclin D1 accumulation is the rate-limiting step for cell cycle entry and the transition from G1 to S phase. The levels of cyclin D1 are elevated in G1 phase, where it interacts with the serine-threonine protein… Read more »