TCO-NHS Ester (axial)
This TCO-NHS Ester is the single axial (minor) diastereomer of the succinimidyl carbonate/NHS-functionalized TCO.
Catalogue number crb7108376 Molecular Weight 267.28 Chemical Composition C13H17NO5 Appearance White to slightly grey crystalline Solubility DMSO, DMF, DCM, THF, Chloroform Chemistry NHS Ester Purity >95% (HPLC) cas 1610931-22-0 Storage -20C Manufacturer Product Number 1509
TCO-NHS Ester is an amine-reactive building block used for the modification of amine-containing molecules in organic media. This product is supplied as a single axial (minor, rel-(1S-2S-5E-pS)) diastereomer. This specially formulated crystalline provides easy handling and an extended shelf life. Axial TCO derivatives demonstrate much higher reactivity in the inverse electron demand cycloaddition (IEDDA) reaction compared to equatorial TCO derivatives. An increase in reactivity of up to 10-fold was reported compared to equatorial TCO derivatives. Furthermore, the axial TCO derivatives undergo cis-trans deactivation at faster rate compared to equatorial TCO derivatives.