TCO-NHS Ester (axial)

  • Description

  • Application Data

Description

This TCO-NHS Ester is the single axial (minor) diastereomer of the succinimidyl carbonate/NHS-functionalized TCO.

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Application Data

Catalogue number crb7108376
Molecular Weight 267.28
Chemical Composition C13H17NO5
Appearance White to slightly grey crystalline
Solubility DMSO, DMF, DCM, THF, Chloroform
Chemistry NHS Ester
Purity >95% (HPLC)
cas 1610931-22-0
Storage -20C
Manufacturer Product Number 1509
Material Safety Data Sheet (MSDS)

TCO-NHS Ester is an amine-reactive building block used for the modification of amine-containing molecules in organic media. This product is supplied as a single axial (minor, rel-(1S-2S-5E-pS)) diastereomer. This specially formulated crystalline provides easy handling and an extended shelf life. Axial TCO derivatives demonstrate much higher reactivity in the inverse electron demand cycloaddition (IEDDA) reaction compared to equatorial TCO derivatives. An increase in reactivity of up to 10-fold was reported compared to equatorial TCO derivatives. Furthermore, the axial TCO derivatives undergo cis-trans deactivation at faster rate compared to equatorial TCO derivatives.

TCO-NHS Ester (axial)

Cat No.Pack SizePriceQty.
25mg£195.00
100mg£535.00
1000mg£1,950.00
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