Sulfo TCO-Maleimide

  • Description

  • Application Data


Sulfo TCO-Maleimide is a water-soluble, sulfhydryl-reactive labelling reagent.

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Application Data

Catalogue number crb7108382
Molecular Weight 457.50
Chemical Composition C17H27N3O8S
Appearance Off-white amorphous solid to semi-solid or oil
Solubility DMSO, DMF, Water
Chemistry Maleimide
Purity >95% (HPLC)
Storage -20C
Manufacturer Product Number 1355
Material Safety Data Sheet (MSDS)

Sulfo TCO-Maleimide is a water-soluble reagent that enables simple and efficient incorporation of TCO moiety onto thiol-containing molecules, including cysteine-containing peptides. The maleimide group specifically and efficiently reacts with reduced thiols (sulfhydryl groups, –SH) at pH 6.5-7.5 to form stable thioether bonds. The sulfonated spacer arm is hydrophilic and greatly improves the solubility of TCO-derivatized molecules in water and, in many cases, making them also soluble in aqueous buffers. The spacer arm is also short and so, adds minimal mass to modified molecules.

Sulfo TCO-Maleimide

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