Anti-p12 antibody

  • Description

  • Application Data

Description

Recognises Murine leukaemia virus (MLV) Gag cleavage product, p12 in Western blot and immunelocalisation with a strong signal and low background noise

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Application Data

Catalogue number crb2005300
Antibody Anti-p12 antibody
Antigen Peptide Protein
Aliases murine leukaemia virus (MLV) Gag cleavage product, p12
Cross-Reactivity murine leukaemia virus (MLV)
Target Protein Species murine leukaemia virus (MLV)
Host Species Rabbit
Antibody Type Polyclonal
Concentration serum
Validation 1:1000 (ELISA)
Target p12
Storage Stabilisers The product should be stored at -20°C for short term storage and long term storage. Avoid repeated freeze/ thaw cycles.
Storage The product should be stored at -20°C for short term storage and long term storage. Avoid repeated freeze/ thaw cycles.
Citations

Wanaguru M, Barry DJ, Benton DJ, O’Reilly NJ, Bishop KN (2018) Murine leukemia virus p12 tethers the capsid-containing pre-integration complex to chromatin by binding directly to host nucleosomes in mitosis. PLoS Pathog 14(6): e1007117. https://doi.org/10.1371/journal.ppat.1007117

References

Brzezinski et al., (2016). Phosphorylation Requirement of Murine Leukemia Virus p12. J Virol. 90(24): 11208.  PMID: 27707931

 

Wight et al., (2014).  The N-Terminus of Murine Leukaemia Virus p12 Protein Is Required for Mature Core Stability. PLoS Pathog10(10): e1004474. PMID: 25356837

Data Sheet Material Safety Data Sheet (MSDS)

P12 is a cleavage product from the murine leukaemia virus (MLV) Gag protein and is essential for various steps in viral replication and during both early and late stages of murine leukaemia virus (MLV) infection.

The N- and C-terminal regions of p12 are sequentially acting domains, both required for p12 function. The N-terminal domain of p12 binds directly to the MLV capsid protein (CA), thus stabilising the capsid shell and viral core. p12 contains the PPPY late-domain (L-domain), which is essential for recruiting HECT ubiquitin ligases which regulate pathways to ensure efficient budding.

Anti-p12 antibody

Cat No.Pack SizePriceQty.
1000mg£110.00
5g£220.00
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