Anti-Lamin A/C antibody
Description
Application Data
Description
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Recognises human lamin A and C in both Western blots and immunohistochemistry with strong signal and low background
Application Data
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| Catalogue number | crb2005011 |
|---|---|
| Antibody | Anti-Lamin A/C antibody |
| Antigen Peptide | KLH conjugated synthetic peptide crb1200292e |
| Protein ID | UnitProtKB - Q8N519 |
| Cross-Reactivity | Human |
| Target Protein Species | Human |
| Host Species | Rabbit |
| Antibody Type | Polyclonal |
| Label | Unconjugated |
| Concentration | 1mg/ml |
| Validation | WB/ELISA/IHC |
| Target | Lamin A/C |
| Storage Stabilisers | This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/ thaw cycles. |
| Family | Intermediate filament (Lamins) |
| Disease Area | Limb-Girdle muscular dystrophy |
| Specificity | Protein |
| Storage | This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/ thaw cycles. |
| References | Cesarini, E., Mozzetta, C., Marullo, F., Gregoretti, F., Gargiulo, A., Columbaro, M., Cortesi, A., Antonelli, L., Di Pelino, S., Squarzoni, S., Palacios, D., Zippo, A., Bodega, B., Oliva, G. and Lanzuolo, C. (2015). Lamin A/C sustains PcG protein architecture, maintaining transcriptional repression at target genes. J Cell Biol, 211(3), 533-551. PMID: 26553927 Gruenbaum, Y. and Foisner, R. (2015). Lamins: Nuclear Intermediate Filament Proteins with Fundamental Functions in Nuclear Mechanics and Genome Regulation. Annu Rev Biochem, 84(1), 31-164. PMID: 25747401
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Nuclear lamin proteins (lamin A, B and C) form a complex structural scaffold, called the nuclear lamina, which is associated with the inside of the nuclear envelope.
Lamins bind to a huge number of nuclear protein complexes and are involved in several processes, including chromatin organisation, gene regulation, genome stability, nuclear and cytoskeletal organisation, mechanical stability, differentiation, and tissue-specific functions. Mutations in lamin proteins result in laminopathies such as muscular dystrophy and the accelerated aging condition, Hutchinson-Gilford progeria.
This antibody recognises human lamin A and C in both Western blots and immunohistochemistry with a strong signal and low background signal.