Anti-KSHV ORF65 antibody
Description
Application Data
Description
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An antibody raised against guanylate cyclase soluble subunit alpha-2 (GUCYA2); GUCYA2 is a negative regulator of guanylyl cyclase activity.
Application Data
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| Catalogue number | crb2005224 |
|---|---|
| Antibody | Anti-KSHV ORF65 antibody |
| Antigen Peptide | KLH conjugated synthetic peptide crb1200467e |
| Protein ID | GenBank: ABD28922.1. UniProtKB - Q2HR63 |
| Aliases | Kaposi sarcoma-associated herpesvirus (KSHV) ORF65, Human gammaherpesvirus 8 ORF65, HHV-8 ORF65, Small capsomere-interacting protein |
| Cross-Reactivity | KSHV |
| Target Protein Species | KSHV |
| Host Species | Rabbit |
| Antibody Type | Polyclonal |
| Concentration | 0.5 mg/ml |
| Validation | WB (1:100), ELISA (1:1000) |
| Target | KSHV ORF65 |
| Storage Stabilisers | The product should be stored at -20°C for for short term storage and long term storage. Avoid repeated freeze/thaw cycles. |
| Specificity | Protein |
| Storage | The product should be stored at -20°C for for short term storage and long term storage. Avoid repeated freeze/thaw cycles. |
| References | Lin et al., (1997). Identification, expression, and immunogenicity of Kaposi’s sarcoma-associated herpesvirus-encoded small viral capsid antigen. J Virol., 71(4): 3069. PMID: 9060668. Chen et al., (2020). Human immunodeficiency virus-associated exosomes promote Kaposi’s sarcoma-associated herpesvirus infection via the epidermal growth factor receptor. J Virol., 94(9): e01782-19. doi: 10.1128/JVI.01782-19. |
Antibody which recognises lytic-phase viral capsid antigen (vp19)/small viral capsid antigen (sVCA), encoded by open reading frame 65 (ORF65) from Kaposi’s sarcoma-associated herpesvirus (KSHV)/human herpesvirus 8 (HHV8). HHV8/KSHV belongs to the gamma-2 or rhadinovirus sub-lineage of the Gammaherpesvirinae subfamily and is strongly associated with AIDS related malignancies. These malignancies include; Kaposi’s sarcoma (KS) – a rare cancer that causes skin and mouth lesions; primary effusion lymphoma (PEL) – a B-cell lymphoma; and Castleman’s disease – characterised by over proliferation of the lymph node.