N-azidoacetylgalactosamine-tetraacylated (Ac4GalNAz)
Description
Application Data
Description
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Ac4GalNAz is an unnatural azido-containing, tetraacylated monosaccharide building block.
Application Data
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Material Safety Data Sheet (MSDS)Catalogue number crb7108411 Molecular Weight 430.37 Appearance White to grey amorphous solid Solubility DMSO, DMF, DCM, THF, Chloroform Purity >90% cas 653600-56-7 Storage -20°C Manufacturer Product Number 1086 Citations Ling et al., (2023). Newly-synthesized Glycoprotein Profiling to Identify Molecular Signatures of Warm Ischemic Injury in Donor Lungs. Am. J. Physiol. doi: 10.1152/ajplung.00412.2022.
Ac4GalNAz is an unnatural azido-containing, tetraacylated monosaccharide building block. This azide-derivative of naturally occurring monosaccharide N-Acetylgalactosamine, the amino sugar derivative of galactose, is used in the investigation of glycoproteins and cellular pathways involving glycosylation.
The azide moiety can be used to ‘tag’ glycoproteins then can be targeted for detection using alkyne-activated reagents (‘click’ chemistry) or phosphine-activated reagents (Staudinger ligation).