Monocyclic Beta-Lactams Are Selective, Mechanism-Based Inhibitors of Rhomboid Intramembrane Proteases

Posted by & filed under Case Studies: Customer's publication, SPECTRUM Peptides: Fluorescent Labelled Peptides.

Monocyclic Beta-Lactams Are Selective, Mechanism-Based Inhibitors of Rhomboid Intramembrane Proteases Chem. Biol. 2011, 6, 325-335 O. Pierrat et al. Rhomboids Discovered a decade ago, Rhomboids are a class of enzymes belonging to the super family of intramembrane proteases which comprises metalloproteases such as site-2 protease (S2P) and aspartyl proteases such as signal peptide peptidase (SPP) and presenilin/g-secretase. They… Read more »

Peptide Arrays September 2013

Posted by & filed under Blog, Exhibitions: Peptide meetings, TRANSPORTER Peptides: Peptide Library.

Peptide Arrays After a first edition in London in 2011, ‘Peptide Arrays’ was back this year in Edinburgh. For those who are not totally familiar with this tool, peptide libraries are traditionally un-purified peptides made on a micro-molar scale and either bound to a membrane or provided unbound in a 96-well plate format. They provide an economic… Read more »

Over-expression of the transcription factor HAND1 causes predisposition towards arrhythmia in mice

Posted by & filed under Antibodies, Blog, Case Studies: Customer's publication, TARGET Antibodies: Polyclonal Antibody Production.

Elevated levels of the cardiac transcription factor Heart- and neural crest derivatives-expressed protein 1 (Hand1) have been reported in several cases of adult cardiac dysrhythmia. Cardiac dysrhythmia is also known as arrhythmia or irregular heartbeat and covers a large heterogeneous group of conditions in which there is abnormal electrical activity in the heart which results in irregular heart… Read more »

Evaluation of Phosphatidylinositol-4-kinase III as a Hepatitis C Virus Drug Target

Posted by & filed under Antibodies, Blog.

Evaluation of Phosphatidylinositol-4-kinase IIIα as a Hepatitis C Virus Drug Target Approximately 2.4% of the human population, corresponding to approximately 160 million individuals is infected with the hepatitis C virus (HCV). The majority of which are chronically infected with the virus which results in serious liver diseases such as cirrhosis and hepatocellular carcinoma (cancer of… Read more »

Society of Laboratory and Automation Screening (SLAS), Florida, January 2013

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Society of Laboratory and Automation Screening (SLAS), Orlando, Florida, January 12-16, 2013-David Singleton and Tim Martin Apparently, high throughput screening and laboratory automation is thriving despite the changes in large pharmaceutical research labs.  This second annual SLAS (formed from 2010 marriage of biological sciences and laboratory automation societies) was attended by 3800 interested participants from 44 countries… Read more »

RSC Protein & Peptide Science Group: Early Stage Researcher Meeting 30 November 2012

Posted by & filed under Blog, Peptides.

Cambridge Research Biochemicals (CRB) recently sponsored the RSC (Royal Society for Chemistry) Protein and Peptide Science Group Early Stage Researcher Meeting which took place on 30th November 2012 at the University College London hosted by Dr Alethea Tabor (Department of Chemistry, UCL). Dr Laurent Caron (Technical Manager for Cambridge Research Biochemicals was recently appointed membership to the RSC Protein and Peptide… Read more »

UKTI’s Asia Pacific Life Science Clinic in Newcastle

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As an experienced exporter in to Western Europe and Northern America, Cambridge Research Biochemicals (CRB) is now looking to pastures new for future business growth. UKTI (UK Trade & Investment) are hosting Asia-Pacific Life Science Clinics (in their 5th year) all week up and down the country and we were fortunate to attend the one-to-one… Read more »

Flu Shots: Immunology for All

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It’s Flu shot season and, if you read social media or chat boards, you’ve likely seen discussion about the risks and benefits of getting a flu shot.   Looking at the issue from the foundations of raising antibodies, I’ll highlight what are the basics of the flu shot and what the risk / benefits are of… Read more »

ELRIG – Pharmaceutical Flow Cytometry & Imaging 10-11 October 2012 at AstraZeneca, Alderley Park

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ELRIG (European Laboratory Robotics Interest Group) is a Not For Profit special interest group focused o­n the use of automation, robotics and instrumentation in the laboratory and also on the wider applications of laboratory automation. The  Pharmaceutical Flow Cytometry & Imaging show, took Cambridge Research Biochemicals (CRB) to AstraZeneca’s superb Conference facilities at Alderley Park, Cheshire, where over… Read more »