Alexa Fluor® 488 Anti-mGluR1 antibody
Description
Application Data
Description
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Recognises metabotropic glutamate receptor 1, a G protein-coupled receptor involved in glutamate neurotransmission. Conjugated to Alexa Fluor® 488 fluorescent dye
Application Data
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Data Sheet Material Safety Data Sheet (MSDS)Catalogue number crb2115006e Antibody Alexa Fluor® 488 Anti-mGluR1 antibody Antigen Peptide KLH conjugated synthetic peptide crb1200278e Protein ID UniProtKB - Q13255 Aliases GRM1, GPRC1A, MGLU1, MGLUR1, PPP1R85, SCAR13, glutamate metabotropic receptor 1, protein phosphatase 1 regulatory subunit 85 Cross-Reactivity Rat, Mouse Host Species Anti-Rabbit Antibody Type Polyclonal Label Labelled with Alexa Fluor® 488 under optimal conditions. Ex: 495nm Em:519nm Concentration 0.34mg/ml Validation ELISA Target mGluR1 Disease Area Neurodegenerative diseases Specificity Protein Citations Bakshi, K., Parihar, R., Goswami, S., Walsh, M., Friedman, E. and Wang, H. (2014). Prenatal Cocaine Exposure Uncouples mGluR1 from Homer1 and Gq Proteins. PLoS ONE, 9(3), e91671. PMID: 24626340
Lopez-Chiriboga, A., Komorowski, L., Kümpfel, T., Probst, C., Hinson, S., Pittock, S. and McKeon, A. (2016). Metabotropic glutamate receptor type 1 autoimmunity. Neurology, 86(11), 1009-1013. PMID: 26888994
References Bakshi, K., Parihar, R., Goswami, S., Walsh, M., Friedman, E. and Wang, H. (2014). Prenatal Cocaine Exposure Uncouples mGluR1 from Homer1 and Gq Proteins. PLoS ONE, 9(3), e91671. PMID: 24626340
Lopez-Chiriboga, A., Komorowski, L., Kümpfel, T., Probst, C., Hinson, S., Pittock, S. and McKeon, A. (2016). Metabotropic glutamate receptor type 1 autoimmunity. Neurology, 86(11), 1009-1013. PMID: 26888994
Metabotropic glutamate receptors (mGluRs) are G protein-coupled receptors that have been divided into three groups based on sequence, putative signal transduction mechanisms, and pharmacologic properties. mGluR1 is a group I receptor. Group I mGluRs are predominantly expressed in the postsynaptic somatodendritic regions, especially in brain areas highly responsive to psychostimulants. mGluR1 is a pivotal regulator of glutamatergic neurotransmission which is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions.
Group I mGluRs are coupled exclusively to Gq protein (Gq/11), a heterotrimeric G protein subunit that activates phospholipase C (PLC) and regulates inositol 1,4,5-tris phosphate (IP3) receptors via association with the synaptic scaffolding protein, Homer.
mGluRs modulate neuronal excitability and development, synaptic plasticity and neurotransmitter release underlying optimal cognitive function. Activation of mGluR1 facilitates long-term depression of parallel fiber–Purkinje cell synapses critical for cerebellar motor learning.
This antibody is conjugated to Alexa Fluor® 488, a popular bright green fluorescent dye with high pH-stability.