Alexa Fluor® 488 Anti-Lamin A/C antibody
Description
Application Data
Description
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Recognises human lamin A and C. Conjugated to Alexa Fluor® 488 fluorescent dye
Application Data
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Data Sheet Material Safety Data Sheet (MSDS)Catalogue number crb2115011e Antibody Alexa Fluor® 488 Anti-Lamin A/C antibody Antigen Peptide KLH conjugated synthetic peptide crb1200292e Protein ID UnitProtKB - Q8N519 Cross-Reactivity Human Host Species Anti-Rabbit Antibody Type Polyclonal Label Labelled with Alexa Fluor® 488 under optimal conditions. Ex: 495nm Em:519nm Concentration 0.57mg/ml Validation ELISA Target Lamin A/C Disease Area Limb-Girdle muscular dystrophy Specificity Protein Citations Cesarini, E., Mozzetta, C., Marullo, F., Gregoretti, F., Gargiulo, A., Columbaro, M., Cortesi, A., Antonelli, L., Di Pelino, S., Squarzoni, S., Palacios, D., Zippo, A., Bodega, B., Oliva, G. and Lanzuolo, C. (2015). Lamin A/C sustains PcG protein architecture, maintaining transcriptional repression at target genes. J Cell Biol, 211(3), 533-551. PMID: 26553927
Gruenbaum, Y. and Foisner, R. (2015). Lamins: Nuclear Intermediate Filament Proteins with Fundamental Functions in Nuclear Mechanics and Genome Regulation. Annu Rev Biochem, 84(1), 31-164. PMID: 25747401
References Cesarini, E., Mozzetta, C., Marullo, F., Gregoretti, F., Gargiulo, A., Columbaro, M., Cortesi, A., Antonelli, L., Di Pelino, S., Squarzoni, S., Palacios, D., Zippo, A., Bodega, B., Oliva, G. and Lanzuolo, C. (2015). Lamin A/C sustains PcG protein architecture, maintaining transcriptional repression at target genes. J Cell Biol, 211(3), 533-551. PMID: 26553927
Gruenbaum, Y. and Foisner, R. (2015). Lamins: Nuclear Intermediate Filament Proteins with Fundamental Functions in Nuclear Mechanics and Genome Regulation. Annu Rev Biochem, 84(1), 31-164. PMID: 25747401
Nuclear lamin proteins (lamin A, B and C) form a complex structural scaffold, called the nuclear lamina, which is associated with the inside of the nuclear envelope.
Lamins bind to a huge number of nuclear protein complexes and are involved in several processes, including chromatin organisation, gene regulation, genome stability, nuclear and cytoskeletal organisation, mechanical stability, differentiation, and tissue-specific functions. Mutations in lamin proteins result in laminopathies such as muscular dystrophy and the accelerated aging condition, Hutchinson-Gilford progeria.
This antibody recognises human lamin A and C in both Western blots and immunohistochemistry with a strong signal and low background noise, and has an Alexa Fluor® 488 dye conjugated to it. Alexa Fluor® 488 is a popular, bright green, PH-stable fluorescent dye.