Alexa Fluor® 488 Anti-Cyclin D1 antibody

£270.00
  • Description

  • Application Data

Description

Recognises Cyclin D1, a key regulator of cell proliferation and tumourigenesis. Antibody is conjugated to Alexa Fluor® 488 fluorescent dye

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Application Data

Catalogue number crb2115024e
Disease Area Cancer, cell cycle
Antibody Alexa Fluor® 488 Anti-Cyclin D1 antibody
Antigen Peptide KLH conjugated synthetic peptide crb1200305e
Protein ID UnitProtKB - P24385
Aliases CCND1
Cross-Reactivity Human
Host Species Anti-Rabbit
Antibody Type Polyclonal
Label Labelled with Alexa Fluor® 488 under optimal conditions. Ex: 495nm Em:519nm
Concentration 0.53mg/ml
Validation ELISA
Target Cyclin D1
Specificity Protein
Citations

Pysz, M., Hao, F., Hizli, A., Lum, M., Swetzig, W., Black, A. and Black, J. (2014). Differential Regulation of Cyclin D1 Expression by Protein Kinase C α and ϵ Signaling in Intestinal Epithelial Cells. J Biol Chem, 289(32), 22268-22283. PMID: 24914206

 

Qie, S. and Diehl, J. (2016). Cyclin D1, cancer progression, and opportunities in cancer treatment. J Mol Med, 94(12), 1313-1326. PMID: 27695879

References

Pysz, M., Hao, F., Hizli, A., Lum, M., Swetzig, W., Black, A. and Black, J. (2014). Differential Regulation of Cyclin D1 Expression by Protein Kinase C α and ϵ Signaling in Intestinal Epithelial Cells. J Biol Chem, 289(32), 22268-22283. PMID: 24914206

 

Qie, S. and Diehl, J. (2016). Cyclin D1, cancer progression, and opportunities in cancer treatment. J Mol Med, 94(12), 1313-1326. PMID: 27695879

Data Sheet Material Safety Data Sheet (MSDS)

Cyclin D1 is a key regulator of cell proliferation and its expression and accumulation within cells is under tight control. Cyclin D1 is the regulatory subunit of cyclin-dependent kinases 4 and 6. These activated cyclin dependent kinases then phosphorylate the retinoblastoma protein (Rb) and drive G1 to S phase progression. Cyclin D1 promotes cell proliferation through interaction with transcription factors such as the oestrogen receptor and specificity protein 1 (Sp1). Cell proliferation is extremely sensitive to altered levels of cyclin D1, with even modest changes in its expression having noticeable effects on cell cycle progression. Cyclin D1 is a proto-oncogene and its overexpression is one of the most frequent alterations seen in multiple cancer types.

This antibody is conjugated to Alexa Fluor® 488. Alexa Fluor® 488 is a popular bright green fluorescent dye with high pH-stability.

Alexa Fluor® 488 Anti-Cyclin D1 antibody

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