WT1 (37-45) Heavy
[U-13C5,15N-Val]-LDFAPPGA-acid
Description
Application Data
Description
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WT1 is a transcription factor that contains four zinc finger motifs at the C-terminus and a proline / glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system. The valine is isotopically labelled with carbon-13(5) and nitro-gen-15(1).
Application Data
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Data Sheet Material Safety Data Sheet (MSDS)Catalogue number crb1300919 Molecular Weight 891.5 Sequence (one letter code) [U-13C5,15N-Val]-LDFAPPGA-acid
Sequence (three letter code) H-[U-13C5,15N-Val]-Leu-Asp-Phe-Ala-Pro-Pro-Gly-Ala-OH
Storage -20°C Citations Han et al (2007) The zinc finger domain of Wilms’ tumor 1 suppressor gene (WT1) behaves as a dominant negative, leading to abrogation of WT1 oncogenic potential in breast cancer cells. Breast Cancer Res. 9 (4) R43 PMID: 17634147
References Han et al (2007) The zinc finger domain of Wilms’ tumor 1 suppressor gene (WT1) behaves as a dominant negative, leading to abrogation of WT1 oncogenic potential in breast cancer cells. Breast Cancer Res. 9 (4) R43 PMID: 17634147
Wilms tumor protein is a protein that is encoded by the WT1 gene on chromosome 11p in humans. WT1 is a tumour suppressor gene associated with the development of Wilms’ Tumour, from which it was named. Mutations in exon 7 and 9 of WT1 have been recurrently identified in acute myeloid leukemia and associated with poorer prognosis and chemotherapy resistance.
The WT1 peptide is a transcription factor that contains four zinc finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system.
WT1 has been ranked by the National Cancer Institute (NCI) as the Number 1 target for cancer immunotherapy.
The valine is isotopically labelled with carbon-13(5) and nitrogen-15(1).